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Titolo:
Potential role of cholecystokinin in the development of acute pancreatitis
Autore:
Beglinger, C;
Indirizzi:
Univ Basel Hosp, Div Gastroenterol, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 ol, CH-4031 Basel, Switzerland
Titolo Testata:
DIGESTION
, volume: 60, anno: 1999, supplemento:, 1
pagine: 61 - 63
SICI:
0012-2823(1999)60:<61:PROCIT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; RECEPTOR ANTAGONIST; INTERLEUKIN-1; RATS; MICE; INHIBITION; MECHANISM; L-364,718; SEVERITY; BLOCKADE;
Keywords:
pancreatitis; cholecystokinin; CCKA receptor antagonists; cytokines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Beglinger, C Univ Basel Hosp, Div Gastroenterol, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 asel, Switzerland
Citazione:
C. Beglinger, "Potential role of cholecystokinin in the development of acute pancreatitis", DIGESTION, 60, 1999, pp. 61-63

Abstract

Evidence based on animal studies suggests that cholecystokinin (CCK) is involved in the induction and development of acute experimental pancreatitis. However, the results obtained with CCK or CCKA receptor antagonists in different species (rats, mice) and different models of acute pancreatitis (cerulein pancreatitis, hemorrhagic pancreatitis induced by choline-deficient, ethionine-supplemented diet, arginine-induced pancreatitis, sodium taurocholate-induced pancreatitis) produced variable results. The route of administration, the specificity and potency of compounds and the design of the study are predictive for the outcome. Based on the available information, CCK appears to play a contributory role in the development of acute experimentalpancreatitis in mice and rats. No conclusions can be drawn from these results with respect to the human disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 06:50:24