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Titolo:
Regulation and possible significance of leptin in humans: leptin in healthand disease
Autore:
Dagogo-Jack, S;
Indirizzi:
Washington Univ, Sch Med, Div Endocrinol Diabet & Metab, St Louis, MO 63110 Washington Univ St Louis MO USA 63110 Diabet & Metab, St Louis, MO 63110
Titolo Testata:
DIABETES REVIEWS
fascicolo: 1, volume: 7, anno: 1999,
pagine: 23 - 38
SICI:
1066-9442(1999)7:1<23:RAPSOL>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN OB GENE; SUBCUTANEOUS ADIPOSE-TISSUE; DEPENDENT DIABETES-MELLITUS; PANCREATIC BETA-CELLS; STAGE RENAL-DISEASE; MOUSE OBESE GENE; BODY-MASS INDEX; GROWTH-FACTOR-I; PLASMA LEPTIN; SERUM LEPTIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
182
Recensione:
Indirizzi per estratti:
Indirizzo: Dagogo-Jack, S Washingtonampus, Sch Med, Div Endocrinol Diabet & Metab, 660 S Euclid Ave,C Washington Univ 660 S Euclid Ave,Campus Box 8127 St Louis MO USA 63110
Citazione:
S. Dagogo-Jack, "Regulation and possible significance of leptin in humans: leptin in healthand disease", DIABET REV, 7(1), 1999, pp. 23-38

Abstract

Interest in the regulation of body weight and the pathophysiology of obesity has been rekindled by the cloning of the obese (ob) gene and identification of its product, leptin. Lepting impressive metabolic effects in mice (inhibition of food intake, stimulation of energy expenditure, reversal of obesity, and amelioration of insulin resistance), though most desirable, are yet to be demonstrated in humans. However, numerous studies in humans indicate that leptin is a regulated hormone that may be involved in diverse physiological and pathophysiological processes, The physiological factors that modulate plasma leptin levels include sex, body fat, exercise, and fluctuations in caloric supply. Plasma leptin levels exhibit a peripubertal surge and a postmenopausal decline, and they are responsive to hormonal manipulations. Hormones that increase leptin production include insulin, glucocorticoids, estradiol, and growth hormone; those that decrease leptin levels include testosterone, somatostatin, and insulin-like growth factor I, End-stage renal disease, a catabolic and anorectic state, is associated with marked elevation in plasma leptin levels. These and other data documenting the presence of leptin in placenta, cord blood, and breast milk and alterations in certain disease states are reviewed in this review focusing on leptin measurement in humans. Understanding the role and regulation of leptin in healthand disease is a prereguisite to a rational utilization of leptin-based regimens in the treatment of disorders of human metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:52:45