Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Role of gingipains R in the pathogenesis of Porphyromonas gingivalis - Mediated periodontal disease
Autore:
Genco, CA; Potempa, J; Mikolajczyk-Pawlinska, J; Travis, J;
Indirizzi:
Boston02118, Sch Med, Dept Med, Maxwell Finland Lab Infect Dis, Boston, MABoston Univ Boston MA USA 02118 axwell Finland Lab Infect Dis, Boston, MA Jagiellonian Univ, Inst Mol Biol, Krakow, Poland Jagiellonian Univ Krakow Poland ian Univ, Inst Mol Biol, Krakow, Poland Univ Georgia, Dept Biochem, Athens, GA 30602 USA Univ Georgia Athens GA USA 30602 rgia, Dept Biochem, Athens, GA 30602 USA
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 3, volume: 28, anno: 1999,
pagine: 456 - 465
SICI:
1058-4838(199903)28:3<456:ROGRIT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR-PERMEABILITY ENHANCEMENT; PROTEINASE ARG-GINGIPAIN; CYSTEINE PROTEINASE; BACTEROIDES-GINGIVALIS; CREVICULAR FLUID; OUTER-MEMBRANE; TRYPSIN-LIKE; POSSIBLE INVOLVEMENT; SERUM ANTIBODIES; ORAL ANAEROBE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Genco, CA BostonSt,iv, Sch Med, Dept Med, Maxwell Finland Lab Infect Dis, 774 Albany Boston Univ 774 Albany St Boston MA USA 02118 ct Dis, 774 Albany
Citazione:
C.A. Genco et al., "Role of gingipains R in the pathogenesis of Porphyromonas gingivalis - Mediated periodontal disease", CLIN INF D, 28(3), 1999, pp. 456-465

Abstract

It has been demonstrated that the Porphyromonas gingivalis cysteine proteinases (gingipains) activate and/or degrade a broad range of host proteins. Inactivation of gingipains R prior to infection of mice results in a decrease in the virulence of P. gingivalis. Analysis of mouse, rabbit, and chicken antisera raised to gingipain R1 demonstrated that the hemagglutinin domains of gingipains are very immunogenic; however, immunization of mice with apeptide derived from the hemagglutinin domain did not protect mice from P.gingivalis infection. Our recent studies indicate that immunization of mice with a peptide corresponding to the N-terminus of the catalytic domain ofgingipains R results in the generation of an immune response that affords protection of mice from P. gingivalis infection. It is postulated that the protection observed results from the inactivation of the enzymatic activityof gingipains R as a result of antibody recognition of a processing site on the gingipain R precursor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 23:46:33