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Titolo:
Perfluorooctyl bromide (perflubron) stimulates mucin secretion in the ferret trachea
Autore:
Kishioka, C; Dorighi, MP; Rubin, BK;
Indirizzi:
Wake Forest Univ, Sch Med, Dept Pediat, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA
Titolo Testata:
CHEST
fascicolo: 3, volume: 115, anno: 1999,
pagine: 823 - 828
SICI:
0012-3692(199903)115:3<823:PB(SMS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; PARTIAL LIQUID VENTILATION; PLATELET-ACTIVATING FACTOR; ARACHIDONIC-ACID; GLYCOCONJUGATE SECRETION; MUCOCILIARY CLEARANCE; EXOGENOUS SURFACTANT; HUMAN AIRWAYS; RELEASE; GLUCOCORTICOIDS;
Keywords:
partial liquid ventilation; mucociliary clearance; secretagogue; arachidonic acid; mucin; lysozyme;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Rubin, BK Wake57orest Univ, Sch Med, Dept Pediat, Med Ctr Blvd, Winston Salem, NC 271 Wake Forest Univ Med Ctr Blvd Winston Salem NC USA 27157 NC 271
Citazione:
C. Kishioka et al., "Perfluorooctyl bromide (perflubron) stimulates mucin secretion in the ferret trachea", CHEST, 115(3), 1999, pp. 823-828

Abstract

Objectives: Partial liquid ventilation with perfluorooctyl bromide (perflubron) has been shown to be safe and effective in animal models with respiratory failure. However, airway mucus accumulation has been reported to be a problem in human trials. We hypothesized that this might be because perflubron directly affects mucociliary clearance or stimulates mucus secretion. Methods and results: We first measured the mucociliary transportability ofsecretions on the mucus-depleted frog palate exposed to perflubron and demonstrated that the ciliated epithelium remained intact with preservation ofmucociliary transport. We then measured mucin and lysozyme secretion from isolated ferret tracheal segments to evaluate the secretagogue potential ofperflubron. There was an 86% increase in mucin secretion with perflubron incubation at 40 min (n = 19; p < 0.01) and a 52% increase after 4 h of exposure followed by evaporation of perflubron (n = 19; p < 0.01). There was nosignificant difference in lysozyme secretion at any time between perflubron-exposed or buffer-exposed tissue (n = 4). The secretagogue effect was completely blocked by nordihydroguaiaretic acid, an inhibitor of arachidonic acid (AA) metabolism. Conclusion: These data suggest that although perflubron does not seem to be harmful to the airway, it induces mucus secretion in a noninflamed airway, and that this can be modulated by inhibitors of AA metabolism.

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Documento generato il 07/04/20 alle ore 23:16:28