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Titolo:
p53 protein overexpression is associated with increased cell proliferationin patients with locally recurrent prostate carcinoma after radiation therapy
Autore:
Cheng, L; Sebo, TJ; Cheville, JC; Pisansky, TM; Slezak, J; Bergstralh, EJ; Pacelli, A; Neumann, RM; Zincke, H; Bostwick, DG;
Indirizzi:
Indiana Univ, Sch Med, Dept Pathol UH 3465, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 H 3465, Indianapolis, IN 46202 USA Mayo Clin & Mayo Fdn, Dept Pathol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 thol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Div Radiat Oncol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 ncol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Biostat Sect, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Sect, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Dept Urol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Urol, Rochester, MN 55905 USA
Titolo Testata:
CANCER
fascicolo: 6, volume: 85, anno: 1999,
pagine: 1293 - 1299
SICI:
0008-543X(19990315)85:6<1293:PPOIAW>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTERNAL-BEAM RADIOTHERAPY; GLUTATHIONE-S-TRANSFERASE; TUMOR-SUPPRESSOR GENE; DNA CONTENT; CANCER; MUTATIONS; EXPRESSION; ANTIGEN; ADENOCARCINOMA; IRRADIATION;
Keywords:
prostate; protein p53; Ki-67 antigen; glutathione S-transferase; recurrent cancer; radiotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Cheng, L IndianaINniv, Sch Med, Dept Pathol UH 3465, 550 N Univ Blvd, Indianapolis, Indiana Univ 550 N Univ Blvd Indianapolis IN USA 46202 ianapolis,
Citazione:
L. Cheng et al., "p53 protein overexpression is associated with increased cell proliferationin patients with locally recurrent prostate carcinoma after radiation therapy", CANCER, 85(6), 1999, pp. 1293-1299

Abstract

BACKGROUND. The biologic changes in recurrent prostate carcinoma followingradiation therapy are not fully understood. The authors sought to determine the level of p53 protein overexpression and its association with cellularproliferation (Ki-67 labeling index), glutathione S-transferase-pi (GST-pi) expression, and other clinical pathologic findings in patients with locally persistent prostate carcinoma after radiation therapy. METHODS. The authors investigated p53 nuclear accumulation, cellular proliferation activity (Ki-67 labeling index by digital image analysis), and GST-pi expression in 55 patients with persistent or recurrent prostate carcinoma after radiation therapy. All patients underwent salvage radical prostatectomy and bilateral pelvic lymphadenectomy following irradiation failure. The interval from radiation therapy to cancer recurrence ranged from 6 months to 17 years (mean, 3.8 years). Age at surgery ranged from 51 to 78 years (mean, 65 years). Mean follow-up after surgery was 5.7 years (range, 1-13 years). RESULTS. p53 protein overexpression was associated with increased cell proliferation (Spearman rank correlation coefficient = 0.29, P = 0.03). A substantial proportion (62%) of recurrent cancer also showed GST-pi immunoreactivity. No apparent correlation was observed between p53 protein overexpression, cellular proliferation (Ki-67 labeling index), or GST-pi expression and Gleason score, pathologic stage, DNA ploidy, or patient outcome. There was an inverse correlation between GST-P expression and Gleason score (P = 0.06). The majority of prostate carcinomas (95%) were proliferative (mean Ki-67 labeling index, 7.0; range, 0-20), whereas concurrent prostatic intraepithelial neoplasia (PIN) had a lower Ki-67 labeling index (mean, 3.1; range,0-11.5). Nineteen of 28 (68%) concurrent PIN demonstrated p53 immunoreactivity. A trend toward adverse clinical outcome was observed in patients witha higher Ki-67 labeling index in recurrent cancer. CONCLUSIONS. In this study cohort selected for salvage prostatectomy, recurrent cancers were biologically aggressive following radiation therapy. Whether this represents selective persistence and regrowth of prognostically unfavorable tumor clonogens or stepwise clonogenic progression is uncertain. Further investigation is needed to elucidate the correlation between p53 overexpression and the presence of other biologic changes after radiation therapy. Cancer 1999;85:1293-9. (C) 1999 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 21:12:11