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Titolo:
Loss of p27(Kip1) expression independently predicts poor prognosis for patients with resectable pancreatic adenocarcinoma
Autore:
Lu, CD; Morita, S; Ishibashi, T; Hara, H; Isozaki, H; Tanigawa, N;
Indirizzi:
Osakapand Coll, Dept Gen & Gastroenterol Surg, Takatsuki, Osaka 5698686, Ja Osaka Med Coll Takatsuki Osaka Japan 5698686 Takatsuki, Osaka 5698686, Ja
Titolo Testata:
CANCER
fascicolo: 6, volume: 85, anno: 1999,
pagine: 1250 - 1260
SICI:
0008-543X(19990315)85:6<1250:LOPEIP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODIES; INHIBITOR P27(KIP1); BREAST-CANCER; TUMOR; CARCINOMA; PROTEIN; CELLS; SIZE; P27;
Keywords:
p27(Kip1) expression; Ki-67; prognosis; pancreatic adenocarcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Tanigawa, N Osaka,Med Coll, Dept Gen & Gastroenterol Surg, 2-7 Daigaku-Machi, Takatsuki Osaka Med Coll 2-7 Daigaku-Machi Takatsuki Osaka Japan 5698686
Citazione:
C.D. Lu et al., "Loss of p27(Kip1) expression independently predicts poor prognosis for patients with resectable pancreatic adenocarcinoma", CANCER, 85(6), 1999, pp. 1250-1260

Abstract

BAGKGROUND. As a universal inhibitor of cyclin-dependent kinases in mammalian cells, p27(Kip1) expression has been implicated in tumor progression and has proved to be a prognostic predictor for several human cancers. In this study, the authors investigated the expression of p27(Kip1) and its potential prognostic significance in patients with resectable pancreatic adenocarcinoma. METHODS. The correlation between p27(Kip1) expression and prognosis was investigated retrospectively in 38 patients who had undergone resection of pancreatic adenocarcinoma including 2 cystadenocarcinomas and 4 mucin-producing tumors. Immunohistochemical staining using an anti-p27(Kip1) antibody, along with an assessment of tumor cell Ki-67 labeling index, was performed on resected specimens. RESULTS. p27(Kip1) expression in pancreatic adenocarcinoma was decreased dramatically when compared with that in normal pancreatic tissue. Based on 35 cases available for survival analysis, loss of p27(Kip1) expression in 16cases defined as having no or <1% p27(Kip1) positive tumor cells showed 1-, 1.5-, and 2-year survival rates of 37.5%, 15.6%, and 0%, respectively, incomparison with 1-, 2-, and 3-year survival rates of 68.4%, 62.2%, and 49.8%, respectively, in the other cases (P = 0.001). After excluding cases of cystadenocarcinoma and mucin-producing tumors, the survival advantage for patients with p27(Kip1) positive tumors remained apparent (P = 0.024]. In each Cox regression model, both those including cystadenocarcinoma and mucin-producing tumors and those that did not, p27(Kip1) expression proved to be an independent predictor for overall survival by multivariate analysis. CONCLUSIONS, These results reveal the significance of p27(Kip1) immunostaining in predicting the outcome of patients with resectable pancreatic adenocarcinoma, adding a novel predictor in the evaluation of prognosis for thislethal disease; Cancer 1999;85:1250-60; (C) 1999 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:48:31