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Titolo:
Role of potassium channels in the antinociception induced by agonists of alpha(2)-adrenoceptors
Autore:
Galeotti, N; Ghelardini, C; Vinci, MC; Bartolini, A;
Indirizzi:
Univ Florence, Dept Preclin & Clin Pharmacol, I-50134 Florence, Italy UnivFlorence Florence Italy I-50134 Pharmacol, I-50134 Florence, Italy
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 5, volume: 126, anno: 1999,
pagine: 1214 - 1220
SICI:
0007-1188(199903)126:5<1214:ROPCIT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS COERULEUS NEURONS; RECEPTOR AGONISTS; PERTUSSIS TOXIN; K+ CHANNELS; GUINEA-PIG; MOUSE; MODULATION; PHARMACOLOGY; INHIBITION; RESPONSES;
Keywords:
K+ channel; antinociception; clonidine; guanabenz; minoxidil; pinacidil; diazoxide; gliquidone; mKvl.l; apamin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Galeotti, N Univorence,ce, Dept Preclin & Clin Pharmacol, Viale Morgagni 65, I-50134 Fl Univ Florence Viale Morgagni 65 Florence Italy I-50134 134 Fl
Citazione:
N. Galeotti et al., "Role of potassium channels in the antinociception induced by agonists of alpha(2)-adrenoceptors", BR J PHARM, 126(5), 1999, pp. 1214-1220

Abstract

1 The effect of the administration of pertussis toxin (PTX) as well as modulators of different subtypes of K+ channels on the antinociception inducedby clonidine and guanabenz was evaluated in the mouse hot plate test.2 Pretreatment with pertussis toxin (0.25 mu g per mouse i.c.v.) 7 days before the hot-plate test, prevented the antinociception induced by both clonidine (0.08-0.2 mg kg(-1), s.c.) and guanabenz (0.1-0.5 mg kg(-1), s.c.).3 The administration of the K-ATP channel openers minoxidil (10 mu g per mouse, i.c.v.), pinacidil (25 mu g per mouse, i.c.v.) and diazoxide (100 mg kg(-1), p.o.) potentiated the antinociception produced by clonidine and guanabenz whereas the K-ATP channel blocker gliquidone (6 mu g per mouse, i.c.v.) prevented the alpha(2) adrenoceptor agonist-induced analgesia.4 Pretreatment with an antisense oligonucleotide (aODN) to mKv1.1, a voltage-gated K+ channel, at the dose of 2.0 nmol per single i.c.v. injection, prevented the antinociception induced by both clonidine and guanabenz in comparison with degenerate oligonucleotide (dODN)-treated mice.5 The administration of the Ca2+-gated K+ channel blocker apamin (0.5-2.0 ng per mouse, i.c.v.) never modified clonidine and guanabenz analgesia.6 At the highest effective doses, none of the drugs used modified animals'gross behaviour nor impaired motor coordination, as revealed by the rota-rod test.7 The present data demonstrate that both K-ATP and mKv1.1 K+ channels represent an important step in the transduction mechanism underlying central antinociception induced by activation of alpha(2) adrenoceptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 05:23:44