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Titolo:
Lung clearance of intratracheally instilled Tc-99m-tobramycin using pulmonary surfactant as vehicle
Autore:
Vant Veen, A; Gommers, D; Verbrugge, SJC; Wollmer, P; Mouton, JW; Kooij, PPM; Lachmann, B;
Indirizzi:
Erasmus Med Ctr, Dept Anaesthesiol, NL-3000 DR Rotterdam, Netherlands Erasmus Med Ctr Rotterdam Netherlands NL-3000 DR Rotterdam, Netherlands Erasmusherlands, Dept Med Microbiol & Infect Dis, NL-3000 DR Rotterdam, Net Erasmus Med Ctr Rotterdam Netherlands NL-3000 DR -3000 DR Rotterdam, Net Erasmus Med Ctr, Dept Nucl Med, NL-3000 DR Rotterdam, Netherlands Erasmus Med Ctr Rotterdam Netherlands NL-3000 DR Rotterdam, Netherlands Malmo Univ Hosp, Dept Clin Physiol, S-21401 Malmo, Sweden Malmo Univ HospMalmo Sweden S-21401 Clin Physiol, S-21401 Malmo, Sweden
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 5, volume: 126, anno: 1999,
pagine: 1091 - 1096
SICI:
0007-1188(199903)126:5<1091:LCOIIT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYSTIC-FIBROSIS; AEROSOLIZED TOBRAMYCIN; GUINEA-PIG; PHARMACOKINETICS; DELIVERY;
Keywords:
pulmonary surfactant; surfactant as carrier; Tc-99m-tobramycin; lung clearance; local antimicrobial therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Lachmann, B Erasmusands Ctr, Dept Anaesthesiol, POB 1738, NL-3000 DR Rotterdam, Netherl Erasmus Med Ctr POB 1738 Rotterdam Netherlands NL-3000 DR erl
Citazione:
A. Van't Veen et al., "Lung clearance of intratracheally instilled Tc-99m-tobramycin using pulmonary surfactant as vehicle", BR J PHARM, 126(5), 1999, pp. 1091-1096

Abstract

1 The use of pulmonary exogenous surfactant as a vehicle for intratracheally administered antibiotics to improve local antimicrobial therapy has beenproposed. The present study investigated lung clearance rates in the rat of intratracheally instilled technetium labelled tobramycin with and withoutthe addition of surfactant to the antibiotic solution.2 The influence of surfactant on Tc-99m-tobramycin lung clearance rates was studied dynamically with a gamma-camera in anaesthetized spontaneously breathing animals and in mechanically ventilated animals.3 The results show that instillation of Tc-99m-tobramycin with use of surfactant as vehicle significantly increases Tc-99m-tobramycin lung clearance compared to instillation of Tc-99m-tobramycin solution alone (P = 0.006 between the two spontaneously breathing groups of animals and P = 0.02 betweenthe two ventilated groups of animals, ANOVA for repeated time measurements). The half life (t1/2) of composite clearance curves in spontaneous breathing animals was 147 min for animals receiving Tc-99m-tobramycin versus 61 min for animals receiving Tc-99m-tobramycin with surfactant. In mechanicallyventilated animals this was 163 min versus 51 min, respectively.4 It is concluded that exogenous surfactant, used as vehicle for intratracheally instilled Tc-99m-tobramycin, increases lung clearance rate of Tc-99m-tobramycin in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 02:41:57