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Titolo:
Cellular localization of brain-derived neurotrophic factor-like immunoreactivity in adult monkey brain
Autore:
Kawamoto, Y; Nakamura, S; Kawamata, T; Akiguchi, I; Kimura, J;
Indirizzi:
Kyoto Univ, Fac Med, Dept Neurol, Kyoto 606, Japan Kyoto Univ Kyoto Japan 606 Univ, Fac Med, Dept Neurol, Kyoto 606, Japan Hyogo Inst Aging Brain & Cognit Disorders, Dept Neuropathol, Himeji, Hyogo, Hyogo Inst Aging Brain & Cognit Disorders Himeji Hyogo Japan eji, Hyogo,
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 821, anno: 1999,
pagine: 341 - 349
SICI:
0006-8993(19990313)821:2<341:CLOBNF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR MESSENGER-RNA; NERVE GROWTH-FACTOR; FOREBRAIN CHOLINERGIC NEURONS; RAT-BRAIN; BASAL FOREBRAIN; FACTOR FAMILY; EXPRESSION; TRKB; BDNF; SURVIVAL;
Keywords:
brain-derived neurotrophic factor; glia; immunohistochemistry; monkey brain; neuron;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Kawamoto, Y Kyoto Univ, Fac Med, Dept Neurol, Kyoto 606, Japan Kyoto UnivKyoto Japan 606 ed, Dept Neurol, Kyoto 606, Japan
Citazione:
Y. Kawamoto et al., "Cellular localization of brain-derived neurotrophic factor-like immunoreactivity in adult monkey brain", BRAIN RES, 821(2), 1999, pp. 341-349

Abstract

Immunohistochemical localization of brain-derived neurotrophic factor (BDNF) in the monkey brain was investigated using a polyclonal anti-BDNF antibody produced in our laboratory. The antibody recognized a single band in monkey brain homogenates, and the estimated molecular weight was approximately14 kDa, which corresponds well to the molecular weight of BDNF monomer. BDNF-like immunoreactivity was observed in the somata and processes of discrete neuronal subpopulations in the monkey brain. BDNF-positive neurons were widely distributed in various structures of the brain, including the cerebral cortex, hippocampus, basal forebrain, basal ganglia, diencephalon, brainstem and cerebellum. In addition, immunopositive glial cells were found in some brain regions. These data suggest that BDNF may exist widely in the monkey brain, and may be concerned with various types of neurons in the monkey central nervous system. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 02/04/20 alle ore 08:45:12