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Titolo:
No association between D-2 dopamine receptor (DRD2) "A" system alleles, orDRD2 haplotypes, and posttraumatic stress disorder
Autore:
Gelernter, J; Southwick, S; Goodson, S; Morgan, A; Nagy, L; Charney, DS;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, Div Mol Psychiat, New Haven, CT USA Yale Univ New Haven CT USA Psychiat, Div Mol Psychiat, New Haven, CT USA VA Connecticut Healthcare Syst, Dept Psychiat, W Haven, CT USA VA Connecticut Healthcare Syst W Haven CT USA Psychiat, W Haven, CT USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 5, volume: 45, anno: 1999,
pagine: 620 - 625
SICI:
0006-3223(19990301)45:5<620:NABDDR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY CATECHOLAMINE EXCRETION; A1 ALLELE; GENE; ALCOHOLISM; D2; LOCUS; SCHIZOPHRENIA; ABUSE; ACTIVATION; SYMPTOMS;
Keywords:
posttraumatic stress disorder; genetic association; D-2 dopamine receptor; TaqI "A" system; candidate genes; haplotypes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Gelernter, J VetSAdm Med Ctr, Dept Psychiat 116A2, 950 Campbell Ave, W Haven, CT 06516 U Vet Adm Med Ctr 950 Campbell Ave W Haven CT USA 06516 06516 U
Citazione:
J. Gelernter et al., "No association between D-2 dopamine receptor (DRD2) "A" system alleles, orDRD2 haplotypes, and posttraumatic stress disorder", BIOL PSYCHI, 45(5), 1999, pp. 620-625

Abstract

Background: Association studies between marker alleles at the D-2 dopaminereceptor gene (DRD2) and various psychiatric illnesses have produced conflicting results. Reports of allelic associations were originally made with alcoholism, bur were then extended to other psychiatric disorders, includingposttraumatic stress disorder (PTSD). Methods: We studied allele frequency of the DRD2 TaqI "A," "B," and "D" system markers in 52 European-American subjects with diagnoses of PTSD (basedon structured interviews). Results: Frequency of the AI allele in this sample was .15, not significantly different from the .19 allele frequency seen in 87 control subjects. Wewere thus unable to replicate the previous reports of allelic association between the DRD2 TaqI "A1" allele and PTSD. There were also no significant differences in allele frequency for the "B" or "D" systems. We then computed three marker (TaqI "A," "B," and "D" system) haplotypes for the sample; DRD2 haplotype frequencies also did not differ between control subjects and subjects with PTSD,Conclusions: We conclude that DRD2 alleles are not associated with PTSD inthis sample, and that genetic variation at the DRD2 locus is not likely tobe an important contributor to risk for this disorder, Biol Psychiatry 1999;45:620-625 (C) 1999 Society of Biological Psychiatry.

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Documento generato il 26/01/20 alle ore 10:02:26