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Titolo:
Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene
Autore:
Manuck, SB; Flory, JD; Ferrell, RE; Dent, KM; Mann, JJ; Muldoon, MF;
Indirizzi:
Univ Pittsburgh, Dept Psychol, Behav Physiol Lab, Pittsburgh, PA 15260 USAUniv Pittsburgh Pittsburgh PA USA 15260 iol Lab, Pittsburgh, PA 15260 USA Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15261 Univ Pittsburgh Pittsburgh PA USA 15261 Human Genet, Pittsburgh, PA 15261 Univ Pittsburgh, Sch Med, Ctr Clin Pharmacol, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA Ctr Clin Pharmacol, Pittsburgh, PA USA New York State Psychiat Inst, Dept Neurosci, New York, NY 10032 USA New York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 5, volume: 45, anno: 1999,
pagine: 603 - 614
SICI:
0006-3223(19990301)45:5<603:AAATAW>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID MONOAMINE; DISRUPTIVE BEHAVIOR DISORDERS; CENTRAL SEROTONERGIC FUNCTION; D-FENFLURAMINE; PERSONALITY-DISORDERS; PROLACTIN RESPONSE; AMINE METABOLITES; NONHUMAN-PRIMATES; CHALLENGE; VIOLENT;
Keywords:
aggression; anger; genetics; serotonin; tryptophan hydroxylase; temperament;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Manuck, SB Univtsburgh,rgh, Dept Psychol, Behav Physiol Lab, 506 EH,4015 OHara St, Pit Univ Pittsburgh 506 EH,4015 OHara St Pittsburgh PA USA 15260 it
Citazione:
S.B. Manuck et al., "Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene", BIOL PSYCHI, 45(5), 1999, pp. 603-614

Abstract

Background: Central nervous system (CNS) serotonergic activity correlates inversely with human aggressive behavior, and individual differences in aggressive disposition are at least partially heritable. This study was conducted to evaluate the possible association between measures of antagonistic behavior and an intronic polymorphism of the gene coding for tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin biosynthesis. Methods: Locally recruited men and women (n = 251) were genotyped for the A218C polymorphism located in intron 7 of the TPH gene. All subjects were administered standard interview and questionnaire indices of aggression and anger-related traits of personality; in a portion of subjects, CNS serotonergic activity was assessed by neuropsychopharmacologic challenge (prolactinresponse to fenfluramine hydrochloride). Results: Per-sons having any TPH U allele scored significantly higher on measures of aggression and tendency to experience unprovoked anger and were more likely to report expressing their anger outwardly than individuals homozygous for the alternate L allele, in men, but not. women, peak prolactin response to fenfluramine was also attenuated among subjects having any U allele, relative to LL homozygotes. Conclusions: Individual differences in aggressive disposition are associated with an intronic polymorphism of the TPH gene in a nonpatient sample of community-derived volunteers, Biol Psychiatry 1999;45:603-614 (C) 1999 Society of Biological Psychiatry.

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Documento generato il 07/07/20 alle ore 18:17:43