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Titolo:
Benefits and pitfalls encountered in psychiatric genetic association studies
Autore:
Malhotra, AK; Goldman, D;
Indirizzi:
NIAAA, Neurogenet Lab, NIH, Rockville, MD 20852 USA NIAAA Rockville MD USA 20852 Neurogenet Lab, NIH, Rockville, MD 20852 USA Hillside Hosp, Unit Mol Psychiat, Glen Oaks, NY 11004 USA Hillside Hosp Glen Oaks NY USA 11004 ol Psychiat, Glen Oaks, NY 11004 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 5, volume: 45, anno: 1999,
pagine: 544 - 550
SICI:
0006-3223(19990301)45:5<544:BAPEIP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-D2 RECEPTOR GENE; GRADIENT GEL-ELECTROPHORESIS; POLYMORPHIC DNA MARKER; CLOZAPINE RESPONSE; 5-HT2A RECEPTOR; LINKAGE DISEQUILIBRIUM; ALLELIC VARIATION; AMERICAN-INDIANS; STRUCTURAL GENE; HIV-1 INFECTION;
Keywords:
gene; genetics; allele; polymorphism; association; psychiatry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Goldman, D NIAAA,,Neurogenet Lab, NIH, 12420 Parklawn Dr,Pk 5 Bldg,Room 451, Rockville NIAAA 12420 Parklawn Dr,Pk 5 Bldg,Room 451 Rockville MD USA 20852
Citazione:
A.K. Malhotra e D. Goldman, "Benefits and pitfalls encountered in psychiatric genetic association studies", BIOL PSYCHI, 45(5), 1999, pp. 544-550

Abstract

The genetic association strategy is currently being applied to a number ofpsychiatric phenotypes including disease vulnerability, personality variation and clinical response to psychotropic drugs. Association studies offer the prospect of identification of the specific alleles that confer significant effects on clinical phenotype. However, if should be noted that this strategy has additional advantages as well as unique drawbacks. In this paper, we review the basic methodology utilized in each step of a typical psychiatric genetic association study and discuss their potential benefits and pitfalls with particular emphasis on the selection of clinical phenotype, theidentification of a candidate gene, the selection of a candidate variant, clinical data set design, and the statistical analysis of association data,With appropriate design and execution, it is hoped that the association strategy will prove to be as successful in psychiatry as it has proven to be in other branches of medicine. Biol Psychiatry 1999;45: 544-550 (C) 1999 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 13:43:57