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Titolo:
Ankle-arm index as a predictor of cardiovascular disease and mortality in the cardiovascular health study
Autore:
Newman, AB; Shemanski, L; Manolio, TA; Cushman, M; Mittelmark, M; Polak, JF; Powe, NR; Siscovick, D;
Indirizzi:
UnivSAittsburgh, Sch Med, Dept Med, Div Geriatr Med, Pittsburgh, PA 15213 U Univ Pittsburgh Pittsburgh PA USA 15213 riatr Med, Pittsburgh, PA 15213 U Univ Washington, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 iv Washington, Seattle, WA 98195 USA NHLBI, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892NHLBI, Bethesda, MD 20892 USA Univ Vermont, Colchester, VT USA Univ Vermont Colchester VT USAUniv Vermont, Colchester, VT USA Univ Bergen, Bergen, Norway Univ Bergen Bergen NorwayUniv Bergen, Bergen, Norway Harvard Univ, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115Harvard Univ, Boston, MA 02115 USA Johns Hopkins Univ, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA ohns Hopkins Univ, Baltimore, MD USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 3, volume: 19, anno: 1999,
pagine: 538 - 545
SICI:
1079-5642(199903)19:3<538:AIAAPO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-HEART-DISEASE; UNRECOGNIZED MYOCARDIAL-INFARCTION; PERIPHERAL ARTERIAL-DISEASE; BLOOD-PRESSURE INDEX; ATHEROSCLEROSIS RISK; OLDER ADULTS; PREVALENCE; PROGNOSIS; STROKE; COHORT;
Keywords:
peripheral vascular diseases; ankle-arm index; ankle-brachial pressure index; cardiovascular diseases, epidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Newman, AB Univ,Pittsburgh, Sch Med, Dept Med, Div Geriatr Med, 3520 5th Ave,Suite 300 Univ Pittsburgh 3520 5th Ave,Suite 300 Pittsburgh PA USA 15213
Citazione:
A.B. Newman et al., "Ankle-arm index as a predictor of cardiovascular disease and mortality in the cardiovascular health study", ART THROM V, 19(3), 1999, pp. 538-545

Abstract

Peripheral arterial disease (PAD) in the legs, measured noninvasively by the ankle-arm index (AAI) is associated with clinically manifest cardiovascular disease (CVD) and its risk factors. To determine risk of total mortality, coronary heart disease, or stroke mortality and incident versus recurrent CVD associated with a low AAI, we examined the relationship of the AAT tosubsequent CVD events in 5888 older adults with and without CVD. The AAT was measured in 5888 participants greater than or equal to 65 years old at the baseline examination of the Cardiovascular Health Study. All participants had a detailed assessment of prevalent CVD and were contacted every 6 months for total mortality and CVD events (including CVD mortality, fatal and nonfatal myocardial infarction, congestive heart failure, angina, stroke, and hospitalized PAD). The crude mortality rate at 6 years was highest (32.3%) in those participants with prevalent CVD and a low AAI (P<0.9), and it was lowest in those with neither of these findings (8.7%, P<0.01), Similar patterns emerged from analysis of recurrent CVD and incident CVD. The risk for incident congestive heart failure (relative risk [RR]=1.61) and for total mortality (RR=1.62) in those without CVD at baseline but with a low AAI remained significantly elevated after adjustment for cardiovascular risk factors. Hospitalized PAD events occurred months to years after the AAI was measured, with an adjusted RR of 5.55 (95% CI, 3.08 to 9.98) in those at riskfor incident events. A statistically significant decline in survival was seen at each 0.1 decrement in the AAI. An AAI of <0.9 is an independent riskfactor for incident CVD, recurrent CVD, and mortality in this group of older adults in the Cardiovascular Health Study.

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Documento generato il 05/12/20 alle ore 23:51:57