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Titolo:
Relationship of plasmin generation to cardiovascular disease risk factors in elderly men and women
Autore:
Sakkinen, PA; Cushman, M; Psaty, BM; Rodriguez, B; Boineau, R; Kuller, LH; Tracy, RP;
Indirizzi:
Univ Vermont, Dept Pathol, Colchester, VT 05446 USA Univ Vermont Colchester VT USA 05446 ept Pathol, Colchester, VT 05446 USA Univ Vermont, Dept Biochem, Colchester, VT 05446 USA Univ Vermont Colchester VT USA 05446 pt Biochem, Colchester, VT 05446 USA Univ Vermont, Dept Med, Colchester, VT 05446 USA Univ Vermont Colchester VT USA 05446 , Dept Med, Colchester, VT 05446 USA Univ Washington, Dept Med, Seattle, WA USA Univ Washington Seattle WA USA niv Washington, Dept Med, Seattle, WA USA Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Epidemiol, Seattle, WA 98195 USA Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Hlth Serv, Seattle, WA 98195 USA Univ Hawaii Manoa, Dept Med, Honolulu, HI 96822 USA Univ Hawaii Manoa Honolulu HI USA 96822 Dept Med, Honolulu, HI 96822 USA NHLBI, Div Epidemiol & Clin Applicat, NIH, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 & Clin Applicat, NIH, Bethesda, MD 20892 USA Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA Univ PittsburghPittsburgh PA USA 15261 idemiol, Pittsburgh, PA 15261 USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 3, volume: 19, anno: 1999,
pagine: 499 - 504
SICI:
1079-5642(199903)19:3<499:ROPGTC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKED-IMMUNOSORBENT-ASSAY; APPARENTLY HEALTHY-MEN; C-REACTIVE PROTEIN; PRODUCT D-DIMER; MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE; ACTIVATOR INHIBITOR-1; PAI-1; ATHEROSCLEROSIS; EVENTS;
Keywords:
blood coagulation; fibrinolysis; myocardial infarction; elderly; diabetes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Tracy, RP Univ05446ont, Dept Pathol, Aquatec Bldg,T205,55A S Park Dr, Colchester, VT Univ Vermont Aquatec Bldg,T205,55A S Park Dr Colchester VT USA 05446
Citazione:
P.A. Sakkinen et al., "Relationship of plasmin generation to cardiovascular disease risk factors in elderly men and women", ART THROM V, 19(3), 1999, pp. 499-504

Abstract

Plasmin-alpha 2-antiplasmin complex (PAP) marks plasmin generation and fibrinolytic balance. We recently observed that elevated levels of PAP predictacute myocardial infarction in the elderly, yet little is known about the correlates of PAP. We measured PAP in 800 elderly subjects who were free ofclinical cardiovascular disease in 2 cohort studies: the Cardiovascular Health Study and the Honolulu Heart Program. Median PAP levels did not differbetween the Cardiovascular Health Study (6.05+/-1.46 nmol/L) and the Honolulu Heart Program (6.11+/-1.44 nmol/L), and correlates of PAP were similar in both cohorts. In CHS, PAP levels increased with age (r=0.30), procoagulant factors (eg, factor VIIc, r=0.15), thrombin activity (prothrombin fragment F1+2, r=0.29), and inflammation-sensitive proteins (eg, fibrinogen, r=0.44; factor VIIIc, r=0.37). PAP was associated with increased atherosclerosis as measured by the ankle-arm index (AAI) (P for trend, less than or equalto 0.001). PAP was negatively related to factors associated with the insulin resistance syndrome (IRS) (eg, fasting insulin, r=-0.26; body mass index, r=-0.26), possibly reflecting an association with plasminogen activator inhibitor-1 (r=-0.29). Although our study did not have sufficient power to detect a significant interaction, PAP and AAI appeared to be more weakly associated in subjects with more manifestations of the IRS: PAP appeared more strongly associated with AAI in the subgroup with 0 or 1 metabolic disorders (P less than or equal to 0.001; slope estimate, -0.14) compared with the subgroup with 2 or more metabolic disorders (P=0.10; slope estimate, -0.08)and in those with non-insulin-dependent diabetes mellitus (P=0.46; slope estimate, -0.04). Although PAP reflects reactive fibrinolysis and is associated with subclinical atherosclerosis, this relationship may be weaker in populations with characteristics of the IRS, possibly reflecting the inhibitory effects of plasminogen activator inhibitor-1 on PAP. Decreased fibrinolysis in the presence of subclinical disease in subjects with hyperinsulinemia or glucose intolerance is consistent with the premise that depressed plasmin generation may enhance the progression of atherosclerosis in these people.

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Documento generato il 30/11/20 alle ore 12:47:54