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Titolo:
Fibrinolytic activation markers predict myocardial infarction in the elderly - The cardiovascular health study
Autore:
Cushman, M; Lemaitre, RN; Kuller, LH; Psaty, BM; Macy, EM; Sharrett, AR; Tracy, RP;
Indirizzi:
Univ Vermont, Dept Pathol, Colchester, VT 05446 USA Univ Vermont Colchester VT USA 05446 ept Pathol, Colchester, VT 05446 USA Univ Vermont, Dept Med, Colchester, VT 05446 USA Univ Vermont Colchester VT USA 05446 , Dept Med, Colchester, VT 05446 USA Univ Washington, Dept Med, Seattle, WA USA Univ Washington Seattle WA USA niv Washington, Dept Med, Seattle, WA USA Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Epidemiol, Seattle, WA 98195 USA Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Hlth Serv, Seattle, WA 98195 USA Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA Univ PittsburghPittsburgh PA USA 15261 idemiol, Pittsburgh, PA 15261 USA NHLBI, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892NHLBI, Bethesda, MD 20892 USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 3, volume: 19, anno: 1999,
pagine: 493 - 498
SICI:
1079-5642(199903)19:3<493:FAMPMI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKED IMMUNOSORBENT-ASSAY; C-REACTIVE PROTEIN; PLASMINOGEN-ACTIVATOR; SUBCLINICAL DISEASE; RISK-FACTORS; D-DIMER; PLASMA; INHIBITOR-1; ATHEROSCLEROSIS; ASSOCIATION;
Keywords:
blood coagulation; fibrinolysis; myocardial infarction; elderly; risk factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Tracy, RP Univ Vermont, Dept Pathol, 55A S Park Dr, Colchester, VT 05446 USA Univ Vermont 55A S Park Dr Colchester VT USA 05446 VT 05446 USA
Citazione:
M. Cushman et al., "Fibrinolytic activation markers predict myocardial infarction in the elderly - The cardiovascular health study", ART THROM V, 19(3), 1999, pp. 493-498

Abstract

Coagulation factor levels predict arterial thrombosis in epidemiological studies, but studies of older persons are needed. We studied 3 plasma antigenic markers of fibrinolysis, viz, plasminogen activator inhibitor-1 (PAI-1), fibrin fragment D-dimer, and plasmin-antiplasmin complex (PAP) for the prediction of arterial thrombosis in healthy elderly persons over age 65. Thestudy was a nested case-control study in the Cardiovascular Health Study cohort of 5201 men and women greater than or equal to 65 years of age who were enrolled from 1989 to 1990. Cases were 146 participants without baselineclinical Vascular disease who developed myocardial infarction, angina, or coronary death during a follow-up of 2.4 years. Controls remained free of cardiovascular events and were matched 1:1 to cases with respect to sex, duration of follow-up, and baseline subclinical Vascular disease status. With increasing quartile of D-dimer and PAP levels but not of PAI-1, there was an independent increased risk of myocardial infarction or coronary death, but not of angina. The relative risk for D-dimer above versus below the median value (greater than or equal to 120 mu g/L) was 2.5 (95% confidence interval, 1.1 to 5.9) and for PAP above the median (greater than or equal to 5.25 nmol/L), 3.1 (1.3 to 7.7). Risks were independent of C-reactive protein and fibrinogen concentrations. There were no differences in risk by sex or presence of baseline subclinical disease. D-dimer and PAP, but not PAI-1, predicted future myocardial infarction in men and women over age 65. Relationships were independent of other risk factors, including inflammation markers. Results indicate a major role for these markers in identifying a high risk of arterial disease in this age group.

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Documento generato il 30/11/20 alle ore 12:45:35