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Titolo:
TDT statistics for mapping quantitative trait loci
Autore:
Xiong, MM; Krushkal, J; Boerwinkle, E;
Indirizzi:
Univ Texas, Ctr Human Genet, Hlth Sci Ctr, Houston, TX 77225 USA Univ Texas Houston TX USA 77225 enet, Hlth Sci Ctr, Houston, TX 77225 USA Univ Texas, Inst Mol Med, Hlth Sci Ctr, Houston, TX 77225 USA Univ Texas Houston TX USA 77225 Med, Hlth Sci Ctr, Houston, TX 77225 USA
Titolo Testata:
ANNALS OF HUMAN GENETICS
, volume: 62, anno: 1998,
parte:, 5
pagine: 431 - 452
SICI:
0003-4800(199809)62:<431:TSFMQT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSMISSION/DISEQUILIBRIUM TEST TDT; DISCORDANT SIB PAIRS; LINKAGE DISEQUILIBRIUM; GENETIC-LINKAGE; ASSOCIATION; HYPERTENSION; RECEPTOR; GENOME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Xiong, MM Univ Texas, Ctr Human Genet, Hlth Sci Ctr, POB 20334, Houston, TX 77225 USA Univ Texas POB 20334 Houston TX USA 77225 Houston, TX 77225 USA
Citazione:
M.M. Xiong et al., "TDT statistics for mapping quantitative trait loci", ANN HUM GEN, 62, 1998, pp. 431-452

Abstract

The original transmission disequilibrium test (TDT), was introduced to test for linkage between a marker and a disease-susceptibility locus (Spielmanet al. 1993). Allison (1997) extended the TDT procedure to quantitative traits. Allison's test, however, is restrictive in that it requires family trios consisting of one heterozygous parent, one homozygous parent and one child, and considers only the situation where the marker locus is analogous to the quantitative trait locus itself. In this paper, we propose, investigate and apply a general TDT for quantitative traits that permits more than one child per family, does not require only one parent to be heterozygous, and allows for the fact that the various alleles at the marker and trait loci may be at varying degree of linkage disequilibrium. We also show that this TDT for quantitative traits is still a valid test of linkage in the presence of population substructure. To provide guidelines for study design, we develop analytic formulae for calculation of the power of the TDT for mapping quantitative trait loci and investigate the impact of various factors onthe power. Power calculations show that the proposed TDT for quantitative traits is more powerful than Allison's basic test statistic and the extremediscordant sib pair linkage method. The proposed TDT statistic for quantitative traits is applied to systolic blood pressure variation in the Rochester Family Heart Study using an extremely discordant sibling pair design.

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Documento generato il 10/04/20 alle ore 14:56:31