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Titolo:
Comparative effectiveness of fluphenazine decanoate injections every 2 weeks versus every 6 weeks
Autore:
Carpenter, WT; Buchanan, RW; Kirkpatrick, B; Lann, HD; Breier, AF; Summerfelt, AT;
Indirizzi:
Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Baltimore, MD 21228 USAUniv Maryland Baltimore MD USA 21228 iat Res Ctr, Baltimore, MD 21228 USA Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21228 USA Univ Maryland Baltimore MD USA 21228 pt Psychiat, Baltimore, MD 21228 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 3, volume: 156, anno: 1999,
pagine: 412 - 418
SICI:
0002-953X(199903)156:3<412:CEOFDI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIC OUTPATIENTS; INTERNATIONAL PILOT; INTERMITTENT; RISPERIDONE; RELAPSE; HALOPERIDOL; MULTICENTER; MEDICATION; PLACEBO; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Carpenter, WT Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, POB 21247, Baltimore, MD Univ Maryland POB 21247 Baltimore MD USA 21228 Baltimore, MD
Citazione:
W.T. Carpenter et al., "Comparative effectiveness of fluphenazine decanoate injections every 2 weeks versus every 6 weeks", AM J PSYCHI, 156(3), 1999, pp. 412-418

Abstract

Objective: Dose reduction strategies for the maintenance treatment of schizophrenia are designed to maintain the benefits of antipsychotic drug therapy while reducing risks. Previous strategies with decanoate preparations have been based on the use of lower doses per injection to achieve dose reduction; these strategies have achieved dose reduction but have resulted in some increase in symptoms. The authors tested a new dose reduction approach: increasing the interval between injections during intramuscular decanoate antipsychotic treatment. Method: Fifty outpatients with schizophrenia or schizoaffective disorder were randomly assigned to receive 25 mg of fluphenazine decanoate intramuscularly either every 2 weeks or every 6 weeks for 54 weeks in a double-blind design. Results: The two dose regimens did not differ significantly in relapse, symptom, or side effect measures. The every-6-weeks regimen was associated with a significant reduction in total antipsychotic exposure. Conclusions: The use of injections every 6 weeks instead of every 2 weeks may increase compliance and improve patients' comfort as wellas decrease cumulative antipsychotic exposure, without increasing relapse rates or symptoms.

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Documento generato il 18/09/20 alle ore 17:00:05