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Titolo:
Alterations in endogenous circadian rhythm of core temperature in senescent Fischer 344 rats
Autore:
McDonald, RB; Hoban-Higgins, TM; Ruhe, RC; Fuller, CA; Horwitz, BA;
Indirizzi:
Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Davis, Dept Nutr, Davis, CA 95616 USA Univ Calif Davis, Sect Neurobiol Physiol & Behav, Davis, CA 95616 USA UnivCalif Davis Davis CA USA 95616 Physiol & Behav, Davis, CA 95616 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 3, volume: 45, anno: 1999,
pagine: R824 - R830
SICI:
0363-6119(199903)45:3<R824:AIECRO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAILURE-TO-THRIVE; SUPRACHIASMATIC NUCLEUS; AGE; YOUNG; WAKEFULNESS; SLEEP;
Keywords:
aging; age-related anorexia; biological age; hypothalamus; suprachiasmatic nucleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: McDonald, RB Univ Calif Davis, Dept Nutr, 1 Shields Ave, Davis, CA 95616 USA Univ Calif Davis 1 Shields Ave Davis CA USA 95616 A 95616 USA
Citazione:
R.B. McDonald et al., "Alterations in endogenous circadian rhythm of core temperature in senescent Fischer 344 rats", AM J P-REG, 45(3), 1999, pp. R824-R830

Abstract

We assessed whether alterations in endogenous circadian rhythm of core temperature (CRT) in aging rats are associated with chronological time or witha biological marker of senescence, i.e., spontaneous rapid body weight loss. CRT was measured in male Fischer 344 (F344) rats beginning at age 689 days and then continuously until death. Young rats were also monitored. The rats were housed under constant dim red light at 24-26 degrees C, and core temperature was recorded every 10 min via biotelemetry. The CRT amplitude ofthe body weight-stable (presenescent) old rats was significantly less thanthat of young rats at all analysis periods. At the onset of spontaneous rapid weight loss (senescence), all measures of endogenous CRT differed significantly from those in the presenescent period. The suprachiasmatic nucleus(a circadian pacemaker) of the senescent rats maintained its light responsiveness as determined by an increase in c-fos expression after a brief light exposure. These data demonstrate that some characteristics of the CRT arealtered slowly with chronological aging, whereas others occur rapidly withthe onset of senescence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 04:24:35