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Titolo:
Effect of individual or combined ablation of the nuclear groups of the lamina terminalis on water drinking in sheep
Autore:
McKinley, MJ; Mathai, ML; Pennington, G; Rundgren, M; Vivas, L;
Indirizzi:
Univ Melbourne, Howard Florey Inst Expt Physiol & Med, Parkville, Vic 3052, Univ Melbourne Parkville Vic Australia 3052 l & Med, Parkville, Vic 3052,
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 3, volume: 45, anno: 1999,
pagine: R673 - R683
SICI:
0363-6119(199903)45:3<R673:EOIOCA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAN PREOPTIC NUCLEUS; SUBFORNICAL ORGAN; ANGIOTENSIN-II; CIRCUMVENTRICULAR ORGANS; PERIVENTRICULAR LESIONS; VASOPRESSIN SECRETION; FOREBRAIN LESIONS; SODIUM APPETITE; C-FOS; RAT;
Keywords:
hypertonicity; subfornical organ; organum vasculosum of the lamina terminalis; median preoptic nucleus; dehydration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: McKinley, MJ Univ Melbourne, Howard Florey Inst Expt Physiol & Med, Parkville, Vic 3052, Univ Melbourne Parkville Vic Australia 3052 ville, Vic 3052,
Citazione:
M.J. McKinley et al., "Effect of individual or combined ablation of the nuclear groups of the lamina terminalis on water drinking in sheep", AM J P-REG, 45(3), 1999, pp. R673-R683

Abstract

The subfornical organ (SFO), organum vasculosum of the lamina terminalis (OVLT), and median preoptic nucleus (MnPO) were ablated either individually or in various combinations, and the effects on drinking induced by either intravenous infusion of hypertonic 4 M NaCl (1.3 ml/min for 30 min) or waterdeprivation for 48 h were studied. Ablation of either the OVLT or SFO alone did not affect drinking in response to intravenous 4 M NaCl, although combined ablation of these two circumventricular organs substantially reduced but did not abolish such drinking. Ablation of the MnPO or MnPO and SFO together also substantially reduced, but did not abolish, drinking in responseto intravenous hypertonic NaCl. Only near-total destruction of the lamina terminalis (OVLT, MnPO, and part or all of the SFO) abolished acute osmotically induced drinking. The large lesions also reduced drinking after water deprivation, whereas none of the other lesions significantly affected such drinking. None of these lesions altered feeding. The results show that all parts of the lamina terminalis play a role in the drinking induced by acuteincreases in plasma tonicity. The lamina terminalis appears to play a lesscrucial role in the drinking response after water deprivation than for thedrinking response to acute intravenous infusion of hypertonic saline.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 01:39:04