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Titolo:
Transplanted hepatocytes proliferate differently after CCl4 treatment and hepatocyte growth factor infusion
Autore:
Gupta, S; Rajvanshi, P; Aragona, E; Lee, CD; Yerneni, PR; Burk, RD;
Indirizzi:
Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Bronx, NY 10461 USAAlbert Einstein Coll Med Bronx NY USA 10461 Res Ctr, Bronx, NY 10461 USA Albert Einstein Coll Med, Canc Res Ctr, Bronx, NY 10461 USA Albert Einstein Coll Med Bronx NY USA 10461 Res Ctr, Bronx, NY 10461 USA Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA Albert Einstein Coll Med Bronx NY USA 10461 Dept Med, Bronx, NY 10461 USA Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10461 USA Albert EinsteinColl Med Bronx NY USA 10461 t Pediat, Bronx, NY 10461 USA Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA Albert Einstein Coll Med Bronx NY USA 10461 Immunol, Bronx, NY 10461 USA Albert Einstein Coll Med, Dept Epidemiol & Social Med, Bronx, NY 10461 USAAlbert Einstein Coll Med Bronx NY USA 10461 cial Med, Bronx, NY 10461 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
fascicolo: 3, volume: 39, anno: 1999,
pagine: G629 - G638
SICI:
0193-1857(199903)39:3<G629:THPDAC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
IV-DEFICIENT RAT; GENE-THERAPY; CARBON-TETRACHLORIDE; LIVER REPOPULATION; STEM-CELLS; PARTIAL-HEPATECTOMY; REGENERATION; PLOIDY; HYPERCHOLESTEROLEMIA; VIVO;
Keywords:
carbon tetrachloride; hepatocyte transplantation; liver regeneration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Gupta, S Albertllmannein Coll Med, Marion Bessin Liver Res Ctr, 1300 Morris Pk Ave,U Albert Einstein Coll Med 1300 Morris Pk Ave,Ullmann 625 Bronx NYUSA 10461
Citazione:
S. Gupta et al., "Transplanted hepatocytes proliferate differently after CCl4 treatment and hepatocyte growth factor infusion", AM J P-GAST, 39(3), 1999, pp. G629-G638

Abstract

To understand regulation of transplanted hepatocyte proliferation in the normal liver, we used genetically marked rat or mouse cells. Hosts were subjected to liver injury by carbon tetrachloride (CCl4), to liver regenerationby a two-thirds partial hepatectomy, and to hepatocellular DNA synthesis by infusion of hepatocyte growth factor for comparative analysis. Transplanted hepatocytes were documented to integrate in periportal areas of the liver. In response to CCl4 treatments after cell transplantation, the transplanted hepatocyte mass increased incrementally, with the kinetics and magnitude of DNA synthesis being similar to those of host hepatocytes. In contrast,when cells were transplanted 24 h after CCl4 administration, transplanted hepatocytes appeared to be injured and most cells were rapidly cleared. When hepatocyte growth factor was infused into the portal circulation either subsequent to or before cell transplantation and engraftment, transplanted cell mass did not increase, although DNA synthesis rates increased in cultured primary hepatocytes as well as in intact mouse and rat livers. These data suggested that procedures causing selective ablation of host hepatocytes will be most effective in inducing transplanted cell proliferation in the normal liver. The number of transplanted hepatocytes was not increased in the liver by hepatocyte growth factor administration. Repopulation of the liver with genetically marked hepatocytes can provide effective reporters for studying liver growth control in the intact animal.

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Documento generato il 28/01/21 alle ore 07:41:42