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Titolo:
Down-regulation of HLA class I antigen-processing molecules in malignant melanoma - Association with disease progression
Autore:
Kageshita, T; Hirai, S; Ono, T; Hicklin, DJ; Ferrone, S;
Indirizzi:
New York Med Coll, Dept Microbiol & Immunol, Valhalla, NY 10595 USA New York Med Coll Valhalla NY USA 10595 & Immunol, Valhalla, NY 10595 USA Kumamoto Univ, Sch Med, Dept Dermatol, Kumamoto 860, Japan Kumamoto Univ Kumamoto Japan 860 Med, Dept Dermatol, Kumamoto 860, Japan
Titolo Testata:
AMERICAN JOURNAL OF PATHOLOGY
fascicolo: 3, volume: 154, anno: 1999,
pagine: 745 - 754
SICI:
0002-9440(199903)154:3<745:DOHCIA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; PROTEASOME-RELATED GENE; MHC CLASS-I; MUTANT MICE; RMA-S; TRANSPORTER; EXPRESSION; CANCER; REGION; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Ferrone, S New York Med Coll, Dept Microbiol & Immunol, Valhalla, NY 10595USA New York Med Coll Valhalla NY USA 10595 Valhalla, NY 10595 USA
Citazione:
T. Kageshita et al., "Down-regulation of HLA class I antigen-processing molecules in malignant melanoma - Association with disease progression", AM J PATH, 154(3), 1999, pp. 745-754

Abstract

Expression of the proteasome subunits LMP2 and LMP7, the MHC-encoded transporter subunits TAP1 and TAP2, and HLA Class I antigens was examined by immunoperoxidase staining in 10 nevi and 98 melanoma lesions (60 primary and 38 metastatic), because these molecules play an important role in the presentation of melanoma-associated peptide antigens to cytotoxic T cells. LMP2 was less frequently expressed than LMP7 in primary and metastatic melanoma lesions. TAP1, TAP2, and HLA Class I antigen expression was more frequently (P < 0.05) down-regulated in metastatic than in primary melanoma lesions and in nevi. A synchronous TAP1, TAP2, and. HLA Class I antigen down-regulation was observed in 58% of primary and 52% of metastatic lesions. TAP and HLA Class I antigen down-regulation in primary lesions was significantly associated with lesion thickness, stage of disease, reduced time to disease progression, and reduced survival. These results suggest that TAP down-regulation plays a role fn the clinical course of malignant melanoma, probably by providing melanoma cells with a mechanism to escape from cytotoxic T lymphocyte recognition during disease progression.

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Documento generato il 04/07/20 alle ore 15:02:53