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Titolo:
Angiotensin II subtype-1 receptor antagonists improve hemodynamic and renal changes without affecting glucose metabolisms in genetic rat model of non-insulin-dependent diabetes mellitus
Autore:
Uehara, Y; Hirawa, N; Kawabata, Y; Numabe, A; Gomi, T; Ikeda, T; Omata, M;
Indirizzi:
Univ Tokyo, Dept Med 2, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo TokyoJapan 1130033 pt Med 2, Bunkyo Ku, Tokyo 1130033, Japan Asahi Hosp, Dept Nephrol, Yokohama, Kanagawa, Japan Asahi Hosp Yokohama Kanagawa Japan pt Nephrol, Yokohama, Kanagawa, Japan Dokkyo Univ, Sch Med, Dept Clin Pathol, Mibu, Tochigi, Japan Dokkyo Univ Mibu Tochigi Japan d, Dept Clin Pathol, Mibu, Tochigi, Japan NTT, Kantoh Teishin Hosp, Div Nephrol, Tokyo, Japan NTT Tokyo JapanNTT, Kantoh Teishin Hosp, Div Nephrol, Tokyo, Japan
Titolo Testata:
AMERICAN JOURNAL OF HYPERTENSION
fascicolo: 1, volume: 12, anno: 1999,
parte:, 1
pagine: 21 - 27
SICI:
0895-7061(199901)12:1<21:AISRAI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOKUSHIMA FATTY RAT; HYPERTENSION; SENSITIVITY; HYPERINSULINEMIA; RESISTANCE; BRADYKININ; PRESSURE; LOSARTAN; INJURY; NIDDM;
Keywords:
angiotensin; angiotensin receptor antagonist; non-insulin-dependent diabetes mellitus; renal injury; hypertension; insulin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Uehara, Y Univ Tokyo, Dept Med 2, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1130033 Tokyo 1130033, Japan
Citazione:
Y. Uehara et al., "Angiotensin II subtype-1 receptor antagonists improve hemodynamic and renal changes without affecting glucose metabolisms in genetic rat model of non-insulin-dependent diabetes mellitus", AM J HYPERT, 12(1), 1999, pp. 21-27

Abstract

The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is a new genetic model of non-insulin-dependent diabetes mellitus (NIDDM). We investigated whether treatment with an angiotensin II (ANGII) subtype-l receptor antagonist delays the onset of NIDDM and attenuates diabetic nephropathy in the OLETF rat. OLETF rats fed a regular chow were treated with ANGII subtype-l receptor antagonists (E4177 or TA606) for 22 weeks. Hemodynamic changes, glucose metabolism, and the effects on diabetic nephropathy were examined. Systolic blood pressure increased in OLETF rats in an age-dependent manner. OLETF rats exhibited increases in plasma concentrations of glucose and insulin and developed glucosuria at the age of 28 weeks. The changes in glucose metabolismwere associated with proteinuria and an increase in urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG). Morphologic investigation revealed nodular lesions in glomeruli in the OLETF rats. The ANGII receptor antagonisttreatment abolished the blood pressure elevation. However, the treatment did not affect plasma glucose and insulin levels and did not significantly reduce glucosuria. Nodular lesions in glomeruli were not improved by the treatment. However, the receptor antagonists significantly reduced proteinuriaand urinary NAG excretion. Multivariate analyses revealed that proteinuriawas determined by systolic blood pressure, lipid metabolism, and glucose levels in plasma. ANGII subtype-l antagonism does not improve glucose metabolism in the OLETF rat model of NIDDM, which has abnormalities in the glucose-uptake system. Blood pressure elevation and part of the proteinuria associated with NIDDM depends on the renin-angiotensin system rather than glucose metabolisms per se. (C) 1999 American Journal of Hypertension, Ltd.

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Documento generato il 01/04/20 alle ore 02:08:38