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Titolo:
IMMOBILIZATION CAUSES LONG-LASTING MATRIX CHANGES BOTH IN THE IMMOBILIZED AND CONTRALATERAL JOINT CARTILAGE
Autore:
JORTIKKA MO; INKINEN RI; TAMMI MI; PARKKINEN JJ; HAAPALA J; KIVIRANTA I; HELMINEN HJ; LAMMI MJ;
Indirizzi:
UNIV KUOPIO,DEPT ANAT,POB 1627 FIN-70211 KUOPIO FINLAND UNIV KUOPIO,DEPT ANAT FIN-70211 KUOPIO FINLAND UNIV KUOPIO,DEPT PATHOL FIN-70211 KUOPIO FINLAND KUOPIO UNIV HOSP,DEPT SURG FIN-70211 KUOPIO FINLAND JYVASKYLA CENT HOSP,DEPT SURG JYVASKYLA FINLAND
Titolo Testata:
Annals of the Rheumatic Diseases
fascicolo: 4, volume: 56, anno: 1997,
pagine: 255 - 261
SICI:
0003-4967(1997)56:4<255:ICLMCB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANINE KNEE CARTILAGE; ARTICULAR-CARTILAGE; GLYCOSAMINOGLYCAN METABOLISM; EXPERIMENTAL OSTEOARTHRITIS; PROTEOGLYCAN AGGREGATION; RUNNING EXERCISE; STIFLE JOINT; IMMOBILIZATION; REMOBILIZATION; REVERSAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
M.O. Jortikka et al., "IMMOBILIZATION CAUSES LONG-LASTING MATRIX CHANGES BOTH IN THE IMMOBILIZED AND CONTRALATERAL JOINT CARTILAGE", Annals of the Rheumatic Diseases, 56(4), 1997, pp. 255-261

Abstract

Objective-The capacity of articular cartilage matrix to recover during 50 weeks of remobilisation after an atrophy caused by 11 weeks of immobilisation of the knee (stifle) joint in 90 degrees flexion startingat the age of 29 weeks, was studied in young beagle dogs. Methods-Proteoglycan concentration (uronic acid) and synthesis ([S-35]sulphate incorporation) were determined in six and three knee joint surface locations, respectively. Proteoglycans extracted from the cartilages were characterised by chemical determinations, gel filtration, and western blotting for chondroitin sulphate epitope 3B3. Results-The proteoglycanconcentrations that were reduced in all sample sites immediately after the immobilisation, remained 14-28% lower than controls after 50 weeks of remobilisation in the patella, the summit of medial femoral condyle, and the superior femoropatellar surface. In the contralateral joint, there was a 49% increase of proteoglycans in the inferior femoropatellar surface after remobilisation, while a 34% decrease was simultaneously noticed on the summit of the medial femoral condyle. Total proteoglycan synthesis was not significantly changed after immobilisation or 50 weeks' remobilisation in the treated or contralateral joint, compared with age matched controls. The chondroitin 6- to 4- sulphate ratio was reduced by immobilisation both in the radioactively labelled and the total tissue proteoglycans. In the remobilised joint, this ratiowas restored in femur, while in tibia it remained at a level lower than controls. Neither immobilisation nor remobilisation induced epitopes recognised by the monoclonal antibody 3B3 on native (undigested) proteoglycans. Conclusion-These results show that the depletion of proteoglycans observed after 11 weeks of immobilisation was not completely restored in certain surface sites after 50 weeks of remobilisation. Thesignificant changes that developed in the contralateral joint during the remobilisation period give further support to the idea that a permanent alteration of matrix metabolism results even from a temporary modification of loading pattern in immature joints.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 12:16:45