Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Protective effects of zinc in indomethacin-induced gastric mucosal injury:evidence for a dual mechanism involving lipid peroxidation and nitric oxide
Autore:
Joseph, RM; Varela, V; Kanji, VK; Subramony, C; Mihas, AA;
Indirizzi:
Vet Adm Med Ctr, Dept Med, Jackson, MS 39216 USA Vet Adm Med Ctr Jackson MS USA 39216 Ctr, Dept Med, Jackson, MS 39216 USA Vet Adm Med Ctr, Dept Pathol, Jackson, MS 39216 USA Vet Adm Med Ctr Jackson MS USA 39216 , Dept Pathol, Jackson, MS 39216 USA Univ Mississippi, Sch Med, Jackson, MS 39216 USA Univ Mississippi JacksonMS USA 39216 ppi, Sch Med, Jackson, MS 39216 USA
Titolo Testata:
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
fascicolo: 2, volume: 13, anno: 1999,
pagine: 203 - 208
SICI:
0269-2813(199902)13:2<203:PEOZII>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; FREE-RADICALS; BLOOD-FLOW; RAT; ACEXAMATE; DAMAGE; SYNTHASE; LESIONS; ULCER; GASTROPROTECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Mihas, AA Vet6Adm Med Ctr, Dept Med, 111A,1500 E Woodrow Wilson Ave, Jackson, MS 3921 Vet Adm Med Ctr 111A,1500 E Woodrow Wilson Ave Jackson MS USA 39216
Citazione:
R.M. Joseph et al., "Protective effects of zinc in indomethacin-induced gastric mucosal injury:evidence for a dual mechanism involving lipid peroxidation and nitric oxide", ALIM PHARM, 13(2), 1999, pp. 203-208

Abstract

Background: Indomethacin causes gastric mucosal injury, although the pathogenesis is not fully understood, Zinc, is known to have gastroprotective effects in both humans and experimental animals. Aim: To determine (i) the protective effects of zinc in indomethacin-induced gastric mucosal injury in rats, and (ii) whether these cytoprotective effects are mediated by changes in gastric lipid peroxidation and/or nitric oxide synthase activity,Methods: Gastric lesions were induced in rats by the intragastric administration of indomethacin. Morphological changes, lipid peroxidation (malondialdehyde levels) and nitric oxide synthase activity were determined in animals pre-treated with zinc sulphate and in controls,Results: Indomethacin significantly increased malondialdehyde levels and decreased NOS activity. These effects were attenuated by pre-treatment with zinc (P < 0.005 and 0.0001, respectively), The protective effects of zinc were readily abolished in animals pretreated with N-nitro-L-arginine methyl ester (L-NAME). Morphologically, indomethacin induced large areas of mucosal ulcerations, which were completely prevented by zinc pre-treatment,Conclusions: Zinc provides protection against indomethacin-induced gastricmucosal injury. These protective effects result from the inhibition of lipid peroxidation and the preservation of mucosal nitric oxide synthase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:31:33