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Titolo:
Neuropsychological impairment correlates with hypoperfusion and hypometabolism but not with severity of white matter lesions on MRI in patients with cerebral microangiopathy
Autore:
Sabri, O; Ringelstein, EB; Hellwig, D; Schneider, R; Schreckenberger, M; Kaiser, HJ; Mull, M; Buell, U;
Indirizzi:
Aachen Univ Technol RWTH, Dept Nucl Med, D-52057 Aachen, Germany Aachen Univ Technol RWTH Aachen Germany D-52057 D-52057 Aachen, Germany Aachen Univ Technol, Dept Neurol, Aachen, Germany Aachen Univ Technol Aachen Germany echnol, Dept Neurol, Aachen, Germany Aachen Univ Technol, Dept Neuroradiol, Aachen, Germany Aachen Univ Technol Aachen Germany l, Dept Neuroradiol, Aachen, Germany Univ Munster, Dept Neurol, D-4400 Munster, Germany Univ Munster Munster Germany D-4400 Dept Neurol, D-4400 Munster, Germany
Titolo Testata:
STROKE
fascicolo: 3, volume: 30, anno: 1999,
pagine: 556 - 566
SICI:
0039-2499(199903)30:3<556:NICWHA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE METABOLIC-RATE; VASCULAR DEMENTIA; BINSWANGERS-DISEASE; BRAIN; LEUKOARAIOSIS; INFARCTS; TOMOGRAPHY; CRITERIA; PATTERNS; VOLUME;
Keywords:
magnetic resonance imaging; microangiopathy; neuropsychological testing; tomography, emission computed; vascular dementia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Sabri, O Aachenmanyv Technol RWTH, Dept Nucl Med, Pauwelsstr 30, D-52057 Aachen, Ger Aachen Univ Technol RWTH Pauwelsstr 30 Aachen Germany D-52057 er
Citazione:
O. Sabri et al., "Neuropsychological impairment correlates with hypoperfusion and hypometabolism but not with severity of white matter lesions on MRI in patients with cerebral microangiopathy", STROKE, 30(3), 1999, pp. 556-566

Abstract

Background and Purpose-Cerebral microangiopathy, indicated on MRI by lacunar infarctions (LI) and deep white matter lesions (DWML), is said to lead to vascular dementia. Methods-Fifty-seven patients with proven cerebral microangiopathy were assessed for changes in regional cerebral blood flow (rCBF) and glucose metabolism (rMRGlu) and compared with 19 age-matched controls. The findings were correlated with results of extensive neuropsychological testing, as well aswith MRI findings. A special head holder ensured reproducibility of positioning during rCBF (single-photon emission CT [SPECT]), rMRGlu (positron emission tomography [PET]), and MR imaging. White matter and cortex were quantified with regions of interest defined on MRI and superimposed to corresponding PET/SPECT slices. LI and DWML were graded by number and extent. Results-Even with severe DWML and multiple LI, rCBF and rMRGlu values werenot reduced. ANOVAs identified brain atrophy and neuropsychological deficits as the main determinants for reduced rCBF and rMRGlu values in both cortex and white matter. Neuropsychological deficits correlated well with decreased rCBF and rMRGlu, whereas MRI patterns such as LI and DWML did not. Factor analysis revealed no correlation of LI and DWML with rCBF, rMRGlu, atrophy, and neuropsychological deficits, showing instead positive correlationsbetween rCBF, rMRGlu, and neuropsychological performance and negative correlations of the latter 3 with brain atrophy. Conclusions-From these data, we conclude that LI and DWML are epiphenomenathat may morphologically characterize cerebral microangiopathy but do not in themselves indicate cognitive impairment. Dementia or neuropsychologicaldeficits. by contrast, are reflected exclusively by functional imaging parameters (rCBF, rMRGlu) and cerebral atrophy.

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Documento generato il 20/01/21 alle ore 03:12:32