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Titolo:
Psychopathological, neuroendocrine and autonomic effects of 3,4-methylenedioxyethylamphetamine (MDE), psilocybin and d-methamphetamine in healthy volunteers - Results of an experimental double blind placebo controlled study
Autore:
Gouzoulis-Mayfrank, E; Thelen, B; Habermeyer, E; Kunert, HJ; Kovar, KA; Lindenblatt, H; Hermle, L; Spitzer, M; Sass, H;
Indirizzi:
Univ74echnol, Rhein Westfal TH Aachen, Dept Psychiat & Psychotherapy, D-520 Univ Technol Aachen Germany D-52074 Dept Psychiat & Psychotherapy, D-520 Univ Tubingen, Inst Pharmaceut, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 maceut, D-72076 Tubingen, Germany Psychiat & Neurol Hosp Christophsbad, D-73035 Goppingen, Germany Psychiat & Neurol Hosp Christophsbad Goppingen Germany D-73035 , Germany Univ Ulm, Dept Psychiat, D-89070 Ulm, Germany Univ Ulm Ulm Germany D-89070 iv Ulm, Dept Psychiat, D-89070 Ulm, Germany
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 142, anno: 1999,
pagine: 41 - 50
Fonte:
ISI
Lingua:
ENG
Soggetto:
MDMA ECSTASY; (+/-)3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; SEROTONERGIC STIMULATION; RECREATIONAL USERS; SUBJECTIVE REPORTS; PANIC DISORDER; RAT-BRAIN; AMPHETAMINE; EVE;
Keywords:
MDE; ecstasy; methamphetamine; psilocybin; entactogens; psychopathology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Gouzoulis-Mayfrank, E Univlsstrnol, Rhein Westfal TH Aachen, Dept Psychiat& Psychotherapy, Pauwe Univ Technol Pauwelsstr 30 Aachen Germany D-52074 e
Citazione:
E. Gouzoulis-Mayfrank et al., "Psychopathological, neuroendocrine and autonomic effects of 3,4-methylenedioxyethylamphetamine (MDE), psilocybin and d-methamphetamine in healthy volunteers - Results of an experimental double blind placebo controlled study", PSYCHOPHAR, 142(1), 1999, pp. 41-50

Abstract

The aim of this study was to contribute to the characterization of the entactogen (ecstasy) substance group. The psychopathological, neuroendocrine and autonomic effects of common recreational doses of the entactogen 3,4-methylenedioxyethylamphetamine (MDE), the hallucinogen psilocybin, the stimulant d-methamphetamine and placebo were investigated in a double-blind study with healthy volunteers (n = 32). Psychological effects of the drugs were assessed by means of standardized rating scales, self assessment inventoriesand free descriptions. The most characteristic effects of MDE were pleasant emotional experiences of relaxation, peacefulness, content and closeness to others. However, significant stimulant and hallucinogen-like effects were also present, although the latter were weaker than the effects of psilocybin. MDE elicited the strongest endocrine and autonomic effects among the three drugs, including robust rises of serum cortisol and prolactin, elevations of blood pressure and heart rate, and a moderate, but significant rise of body temperature. The apparent contrast between psychological and autonomic effects (subjective relaxation versus physical activation) was a uniquefeature of the MDE state. Our findings are in line with both users' reports and results from previous experimental studies, and support the view thatentactogens constitute a distinct psychoactive substance class taking an intermediate position between hallucinogens and stimulants.

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Documento generato il 04/06/20 alle ore 00:27:19