Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Escalating dose-binge stimulant exposure: relationship between emergent behavioral profile and differential caudate-putamen and nucleus accumbens dopamine responses
Autore:
Segal, DS; Kuczenski, R;
Indirizzi:
Univ Calif San Diego, Sch Med, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 142, anno: 1999,
pagine: 182 - 192
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; INTERSTITIAL CONCENTRATIONS; EXTRACELLULAR DOPAMINE; INVIVO MICRODIALYSIS; AMPHETAMINE; COCAINE; SENSITIZATION; AMYGDALA; RAT; PSYCHOSTIMULANTS;
Keywords:
amphetamine; microdialysis; caudate-putamen; methamphetamine; dopamine; nucleus accumbens; binge; stereotypy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Segal, DS Univa,alif San Diego, Sch Med, Dept Psychiat, 0667,9500 Gillman Dr, La Joll Univ Calif San Diego 0667,9500 Gillman Dr La Jolla CA USA 92093
Citazione:
D.S. Segal e R. Kuczenski, "Escalating dose-binge stimulant exposure: relationship between emergent behavioral profile and differential caudate-putamen and nucleus accumbens dopamine responses", PSYCHOPHAR, 142(2), 1999, pp. 182-192

Abstract

Previous studies showed that treatment with high doses of amphetamine (8.0mg/kg) administered according to an escalating dose-binge regimen, produced a unique behavioral profile that included a decrease in the duration of stereotypy and a pronounced increase in ambulation. characterized by a. repeated bursting pattern of locomotion. This treatment regimen also resulted in differential dopamine response profiles in the caudate-putamen and nucleus accumbens: the dopamine response in the caudate-putamen exhibited a progressive within and between binge decline in peak levels. whereas the dopamine response in the nucleus accumbens was not significantly altered. The present study was designed to determine if this behavioral/dopamine response relationship was obtained under two additional conditions: first. in responseto a relatively low dose amphetamine challenge (2.5 mg/kg) after withdrawal from escalating dose-binge treatment with either amphetamine: or methamphetamine (6.0 mg/kg), and, second. during a lower dose (2.5 mg/kg amphetamine) escalating dose-binge regimen. Both the emergent behavioral profile and the regional differences in the dopamine response patterns were obtained under each set of conditions. These effects may be significantly implicated in the induction of stimulant psychosis since the psychotogenic effects of amphetamine-like stimulants are most commonly associated with frequent, relatively high dose binge exposures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:47:12