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Titolo:
3,3',4,4'-TETRACHLOROBIPHENYL AFFECTS CORTISOL DYNAMICS AND HEPATIC-FUNCTION IN RAINBOW-TROUT
Autore:
VIJAYAN MM; FEIST G; OTTO DME; SCHRECK CB; MOON TW;
Indirizzi:
UNIV BRITISH COLUMBIA,DEPT ANIM SCI VANCOUVER BC V6T 1Z4 CANADA OREGON STATE UNIV,DEPT FISHERIES & WILDLIFE CORVALLIS OR 97331 UNIV OTTAWA,DEPT BIOL OTTAWA ON CANADA
Titolo Testata:
Aquatic toxicology
fascicolo: 2-3, volume: 37, anno: 1997,
pagine: 87 - 98
SICI:
0166-445X(1997)37:2-3<87:3ACDAH>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SALMON ONCORHYNCHUS-KISUTCH; HEPATOCYTE METABOLISM; GLYCOGEN-METABOLISM; CORTICOSTEROIDS; RESPONSIVENESS; MICROSOMES; CATABOLISM; EXCRETION; HORMONES; ENZYMES;
Keywords:
3,3',4,4'-TETRACHLOROBIPHENYL; CORTISOL; P-450; METABOLISM; RAINBOW TROUT; HEPATOCYTES; TOXICANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
M.M. Vijayan et al., "3,3',4,4'-TETRACHLOROBIPHENYL AFFECTS CORTISOL DYNAMICS AND HEPATIC-FUNCTION IN RAINBOW-TROUT", Aquatic toxicology, 37(2-3), 1997, pp. 87-98

Abstract

This study investigates the impact of 3,3',4,4'-tetrachlorobiphenyl (TCBP), a polychlorinated biphenyl (PCB) congener and cytochrome P-450 inducer, on cortisol dynamics in rainbow trout (Oncorhynchus mykiss), Trout were given either an intraperitoneal implant of corn oil alone or corn oil containing TCBP (5 mg kg(-1) body weight) and sampled 6 weeks later. TCBP-implanted fish had significantly lower condition factorand plasma glucose concentration, whereas plasma cortisol and protein, and hepatocyte protein concentration and liver ethoxyresorufin-O-deethylase (EROD) activity was significantly higher compared with the sham group. There was no significant difference in plasma lactate and amino acid concentration, hepatocyte glycogen content or liver cytosolic cortisol binding affinity or capacity between the two groups. [H-3]Cortisol uptake was significantly higher in hepatocytes isolated from TCBP-treated fish compared with the sham fish, Also, our preliminary results suggest that the catabolism of [H-3]cortisol by hepatocytes of TCBP-treated fish was enhanced as noted by a decrease in cortisol-specific radioactivity and an increase in tetrahydrocortisone (a cortisol metabolite) specific radioactivity. These results support a role for TCBPin enhancing cortisol clearance by hepatocytes of trout and suggest that toxicants like PCBs may impair the ability of trout to elicit a physiological response normally associated with cortisol stimulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:54:50