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Titolo:
Nonchemotherapy drug-induced agranulocytosis: A review of 118 patients treated with colony-stimulating factors
Autore:
Beauchesne, MF; Shalansky, SJ;
Indirizzi:
Hop Sacre Coeur, Dept Pharm, Montreal, PQ H4J 1C5, Canada Hop Sacre CoeurMontreal PQ Canada H4J 1C5 , Montreal, PQ H4J 1C5, Canada St Pauls Hosp, Dept Pharm, Vancouver, BC V6Z 1Y6, Canada St Pauls Hosp Vancouver BC Canada V6Z 1Y6 , Vancouver, BC V6Z 1Y6, Canada
Titolo Testata:
PHARMACOTHERAPY
fascicolo: 3, volume: 19, anno: 1999,
pagine: 299 - 305
SICI:
0277-0008(199903)19:3<299:NDAARO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLOZAPINE-INDUCED AGRANULOCYTOSIS; SULFASALAZINE-INDUCED AGRANULOCYTOSIS; FACTOR G-CSF; CARBIMAZOLE-INDUCED AGRANULOCYTOSIS; METHIMAZOLE-INDUCED AGRANULOCYTOSIS; HEMATOPOIETIC GROWTH-FACTORS; INDUCED GRANULOCYTOPENIA; FILGRASTIM TREATMENT; THERAPY; NEUTROPENIA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Beauchesne, MF Hopanadae Coeur, Dept Pharm, 5400 Blvd Gouin Ouest, Montreal, PQ H4J 1C5, C Hop Sacre Coeur 5400 Blvd Gouin Ouest Montreal PQ Canada H4J 1C5
Citazione:
M.F. Beauchesne e S.J. Shalansky, "Nonchemotherapy drug-induced agranulocytosis: A review of 118 patients treated with colony-stimulating factors", PHARMACOTHE, 19(3), 1999, pp. 299-305

Abstract

To determine the role of growth factors in nonchemotherapy drug-induced agranulocytosis, we reviewed 118 published reports of administration of colony-stimulating factors for the disorder. Main outcomes were total duration of neutropenia and mortality. The mean time to neutrophil recovery was 4.6 +/- 3.2 days and 7.7 +/- 5.1 days in patients with a granulocyte count at diagnosis of 0.1-0.5 x 10(3)/mm(3) and less than 0.1 x 10(3)/mm(3), respectively. The mortality rate was 4.2%. Without therapy with growth factors, the mean time to neutrophil recovery after discontinuation of the offending agent was reported to be 10 +/- 8 days. The mortality rate was 16% in one study. We conclude that hematopoietic growth factors may shorten the duration of neutropenia and reduce mortality in patients with severe drug-induced agranulocytosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:51:11