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Titolo:
Prognostic significance of tumor angiogenesis in endometrial cancer
Autore:
Obermair, A; Tempfer, C; Wasicky, R; Kaider, A; Hefler, L; Kainz, C;
Indirizzi:
UnivaHosp Vienna, Dept Obstet & Gynecol, Div Gynecol, A-1090 Vienna, Austri Univ Hosp Vienna Vienna Austria A-1090 iv Gynecol, A-1090 Vienna, Austri Univ Hosp Vienna, Dept Pathol, Gynecopathol Unit, A-1090 Vienna, Austria Univ Hosp Vienna Vienna Austria A-1090 thol Unit, A-1090 Vienna, Austria Univ Hosp Vienna, Dept Med Comp Sci Clin Biometr, A-1090 Vienna, Austria Univ Hosp Vienna Vienna Austria A-1090 n Biometr, A-1090 Vienna, Austria
Titolo Testata:
OBSTETRICS AND GYNECOLOGY
fascicolo: 3, volume: 93, anno: 1999,
pagine: 367 - 371
SICI:
0029-7844(199903)93:3<367:PSOTAI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR ENDOTHELIAL-CELLS; MICROVESSEL DENSITY; STAGE-I; CARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Obermair, A Univ0,osp Vienna, Dept Obstet & Gynecol, Div Gynecol, Wahringer Gurtel 18-2 Univ Hosp Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090
Citazione:
A. Obermair et al., "Prognostic significance of tumor angiogenesis in endometrial cancer", OBSTET GYN, 93(3), 1999, pp. 367-371

Abstract

Objective: To determine the prognostic effect of intratumor microvessel density in a series of unselected patients with endometrial carcinoma. Methods: We reviewed 93 consecutive patients treated surgically for endometrial cancer at the University Hospital of Vienna between 1983 and 1989. Histologic sections were obtained from original paraffin-embedded blocks and stained immunohistochemically for CD34 antigen. Microvessel density was determined by enumeration of intratumor CD34-positive cells under a light microscope at 200 x magnification using an examination area of 0.74 mm(2). Log-rank test and Cox proportional-hazards models (univariate and multivariate)were applied for overall survival analysis. Results: Overall, the 25% quantile of survival was reached at 37.9 months. The 5-year survival rate was 82.2% in 69 patients whose tumors had microvessel counts no more than 100/0.74 mm(2) field, and 52.0% in 24 patients whose tumors had microvessel counts of more than 100/0.74 mm(2) field (log-rank P = .004). In the multiple Cox model, high microvessel counts (relative risk [RR] 1.2; 95% confidence interval [CI] 1.1, 1.4) as well as undifferentiated tumors (RR 6.1; CI 2.2, 16.8), and advanced stage of disease (RR 2.6;CI 1.3, 5.1) independently exerted an adverse influence on the survival ofpatients with endometrial cancer. Conclusion: High intratumor microvessel count is associated with poor survival of patients with endometrial cancer. (C) 1999 by The American College of Obstetricians and Gynecologists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 06:08:14