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Titolo:
THE ENHANCING MECHANISM OF CAPRIC ACID (C10) FROM A SUPPOSITORY ON RECTAL DRUG ABSORPTION THROUGH A PARACELLULAR PATHWAY
Autore:
TAKAHASHI H; SHIBASAKI T; TAKESHITA K; KAIHO F; HAYASHI M;
Indirizzi:
SCI UNIV TOKYO,FAC PHARMACEUT SCI,DEPT PHARMACEUT,SHINJUKU KU,12 ICHIGAYA FUNAGAWARA MACHI TOKYO 162 JAPAN SCI UNIV TOKYO,FAC PHARMACEUT SCI,DEPT PHARMACEUT,SHINJUKU KU TOKYO 162 JAPAN
Titolo Testata:
Biological & pharmaceutical bulletin
fascicolo: 4, volume: 20, anno: 1997,
pagine: 446 - 448
SICI:
0918-6158(1997)20:4<446:TEMOCA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SODIUM CAPRATE; CACO-2 CELLS; AGENTS;
Keywords:
CAPRIC ACID; ABSORPTION ENHANCER; RECTAL ABSORPTION; SUPPOSITORY; PARACELLULAR PATHWAY; ACTIN FILAMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
H. Takahashi et al., "THE ENHANCING MECHANISM OF CAPRIC ACID (C10) FROM A SUPPOSITORY ON RECTAL DRUG ABSORPTION THROUGH A PARACELLULAR PATHWAY", Biological & pharmaceutical bulletin, 20(4), 1997, pp. 446-448

Abstract

Capric acid (C10) enhanced the absorption of cefoxitin sodium in a concentration-dependent manner following the rectal administration as a suppository in rats, Tile optimal concentration of C10 was 13%. CIO administered as a suppository also reduced rectal membrane resistance (R-m), showing that the above enhancing effect was induced by widening the paracellular pathway. Both the enhancing Effect. on the absorption and the reducing effect on R-m were inhibited by W7, an inhibitor of myosin light chain kinase, These results supported that, as shown in the ill vitro Caco-2 cell sg stem, tile C10 effect on the paracellular pathway is due to activating the contraction of Ca2+-calmodulin-dependent actin filament.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:58:00