Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Anxiogenic effect of central CCK administration is attenuated by chronic fluoxetine or ipsapirone treatment
Autore:
To, CT; Bagdy, G;
Indirizzi:
NatlHungarysychiat & Neurol, Lab Neurochem & Expt Med, H-1281 Budapest 27,Natl Inst Psychiat & Neurol Budapest Hungary 27 Med, H-1281 Budapest 27,
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 2, volume: 38, anno: 1999,
pagine: 279 - 282
SICI:
0028-3908(199902)38:2<279:AEOCCA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; CHOLECYSTOKININ TETRAPEPTIDE; SOCIAL-INTERACTION; 5-HT1A RECEPTORS; PANIC DISORDER; B RECEPTOR; ANXIETY; RAT; FLUVOXAMINE; ANTAGONISTS;
Keywords:
anxiety; cholecystokinin octapeptide (CCK-S); 5-HT1A receptor; serotonin (5-HT); social interaction test; SSRI antidepressant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Bagdy, G Natlstnst Psychiat & Neurol, Lab Neurochem & Expt Med, POB 1, H-1281 Budape Natl Inst Psychiat & Neurol POB 1 Budapest Hungary 27 281 Budape
Citazione:
C.T. To e G. Bagdy, "Anxiogenic effect of central CCK administration is attenuated by chronic fluoxetine or ipsapirone treatment", NEUROPHARM, 38(2), 1999, pp. 279-282

Abstract

The effect of chronic fluoxetine and ipsapirone treatment on the anxiogenic effect of centrally administered cholecystokinin (CCK) was studied in thesocial interaction test in male Sprague-Dawley rats. Intracerebroventricular injection of unsulfated CCK-8 significantly decreased total interaction time and locomotor activity and caused some increase in selfgrooming and a reduction in rearing behaviour in a familiar arena in low light conditions. The selective serotonin reuptake inhibitor antidepressant fluoxetine alone(5 mg/kg, i.p.) also had clear acute anxiogenic actions (decrease in totalinteraction time, locomotor activity, rearing, increase in selfgrooming) after single dosing, but all these effects were omitted after chronic (3 weeks) treatment. In contrast, a single injection of the 5-HT1A receptor partial agonist ipsapirone (5 mg/kg, i.p.) alone had only motor effects (decrease in selfgrooming and rearing), and these effects were preserved after chronic treatment. Chronic fluoxetine treatment (5 mg/kg per day, 3 weeks) abolished the effects of CCK-8 (1 nmol/rat, i.c.v.). Chronic treatment with ipsapirone (5 mg/kg per day, 3 weeks) partially attenuated the effects of CCK-8 (1 nmol/rat, i.c.v.). Our studies provide further evidence for a 5-HT/CCKinteraction in the regulation of anxiety. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:27:45