Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANTIFIBROTIC EFFECTS OF A POLYSACCHARIDE EXTRACTED FROM GANODERMA-LUCIDUM, GLYCYRRHIZIN, AND PENTOXIFYLLINE IN RATS WITH CIRRHOSIS INDUCED BY BILIARY OBSTRUCTION
Autore:
PARK EJ; KO GN; KIM JB; SOHN DH;
Indirizzi:
WONKWANG UNIV,COLL PHARM,MED RESOURCES RES CTR GEONBUK 570749 SOUTH KOREA WONKWANG UNIV,COLL PHARM,MED RESOURCES RES CTR GEONBUK 570749 SOUTH KOREA
Titolo Testata:
Biological & pharmaceutical bulletin
fascicolo: 4, volume: 20, anno: 1997,
pagine: 417 - 420
SICI:
0918-6158(1997)20:4<417:AEOAPE>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC-FIBROSIS; INTERFERON-GAMMA; LIVER; COLLAGEN; PROLIFERATION; INHIBITION; THERAPY;
Keywords:
GANODERMA LUCIDUM; GLYCYRRHIZIN; PENTOXIFYLLINE; ANTIFIBROTIC AGENT; BILE DUCT LIGATION/SCISSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
E.J. Park et al., "ANTIFIBROTIC EFFECTS OF A POLYSACCHARIDE EXTRACTED FROM GANODERMA-LUCIDUM, GLYCYRRHIZIN, AND PENTOXIFYLLINE IN RATS WITH CIRRHOSIS INDUCED BY BILIARY OBSTRUCTION", Biological & pharmaceutical bulletin, 20(4), 1997, pp. 417-420

Abstract

For the past few years, we have been investigating polysaccharides from Ganoderma lucidum as antifibrotic agents. In a previous study, we discovered that polysaccharides extracted from G. lucidum lowered the collagen content in liver but had no effect on serum biochemical parameters in rats subjected to bile duct ligation and scission-induced fibrosis. In this study, we changed the extraction method and obtained polysaccharides extracted from G. lucidum. The polysaccharide from G. lucidum reduced the serum aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and total bilirubin and also reduced the collagen content in liver and improved the morphology. Pentoxifylline, which is reported to exhibit an antifibrotic effect in pigs with fibrosis induced by yellow phosphorus, did not have any antifibrotic effects in fibrosis induced by biliary obstruction. Glycyrrhizin, which is used in the treatment of hepatitis, reduced serum ALT and ASTvalues but there was no significance. It had no effect on liver hydroxyproline content,which implies that glycyrrhizin has no antifibrotic effect in the rats with fibrosis induced by bile duct ligation and scission. These data suggest that the polysaccharide from Ganoderma lucidum could be a promising antifibrotic agent. However, further study is needed to understand the inhibition mechanism of collagen deposition of polysaccharides from Ganoderma lucidum and its clinical applicability remains to be established.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 11:35:53