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Titolo:
Acute intrahippocampal injection of human interleukin-1 beta stimulates the anterior pituitary POMC transcription and increases plasma levels of ACTHand corticosterone in the male rat
Autore:
Parsadaniantz, SM; Dauge, V; Roques, BP; Kerdelhue, B;
Indirizzi:
CNRS, Neurobiol Cellulaire & Mol Lab, F-75006 Paris, France CNRS Paris France F-75006 ol Cellulaire & Mol Lab, F-75006 Paris, France Fac Pharm, CNRS, INSERM,U266, Lab Pharmacochim Mol & Struct, Paris, FranceFac Pharm Paris France 66, Lab Pharmacochim Mol & Struct, Paris, France
Titolo Testata:
NEUROENDOCRINOLOGY
fascicolo: 2, volume: 69, anno: 1999,
pagine: 77 - 87
SICI:
0028-3835(199902)69:2<77:AIIOHI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; PROOPIOMELANOCORTIN GENE-EXPRESSION; RECEPTOR MESSENGER-RNA; TUMOR-NECROSIS-FACTOR; CYCLOOXYGENASE PATHWAY; ADRENAL AXIS; I RECEPTOR; BRAIN; ACTIVATION; LOCALIZATION;
Keywords:
interleukins; proopiomelanocortin; corticotropin; adrenal steroids; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Parsadaniantz, SM CNRS,Francebiol Cellulaire & Mol Lab, EP 1591,4 Ave Observ, F-75006 Paris, CNRS EP 1591,4 Ave Observ Paris France F-75006 6 Paris,
Citazione:
S.M. Parsadaniantz et al., "Acute intrahippocampal injection of human interleukin-1 beta stimulates the anterior pituitary POMC transcription and increases plasma levels of ACTHand corticosterone in the male rat", NEUROENDOCR, 69(2), 1999, pp. 77-87

Abstract

It has been well documented that interleukin-1 beta (IL-1 beta) is a majormediator for recruiting the hypothalamo-pituitary-adrenal (HPA) axis following infectious disease. The recent localization of IL-1 beta receptors in neurons of the hippocampus provides further support for the role of IL-1 beta as a neurotransmitter/neuromodulator in the central nervous system. In this study, we investigated whether an acute intrahippocampal injection of IL-1 beta is able to rapidly stimulate HPA activity. Seven days after bilateral implantation of a guide cannula into the hippocampus, human IL-1 beta (10 ng/0.5 mu l/side) was injected to freely moving male rats. Following this, animals were sacrificed at times 20, 45 and 90 min postinjection and a kinetic analysis of hIL-1 beta action on plasma ACTH and corticosterone (CORT) concentrations and nuclear processing of the anterior pituitary (AP) proopiomelanocortin (POMC) was conducted. Intrahippocampal administration of hIL-1 beta significantly increased both plasma ACTH and CORT concentrations at 45 and 90 min postinjection. This increase in ACTH concentration paralleled a rise in AP POMC gene transcription. Moreover, the increase in AP POMCprimary transcript was followed by an increase in AP POMC intermediate processing RNA. However, at these times, no significant hIL-1 beta effect on the level of AP nuclear POMC mRNA was observed. Almost identical results were obtained after intraperitoneal injection of hIL-1 beta. In conclusion, our data demonstrates that the hippocampal IL-1 beta/IL-1 beta receptor is directly and rapidly implicated in HPA activation, in the same manner as thatobserved after intraperitoneal administration of hIL-1 beta. These resultsshow that IL-1 action in the hippocampus could be of immunoneuroendocrine significance for the HPA axis activation during inflammatory states.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 14:15:02