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Titolo:
Abnormal distribution of mesangium-specific laminin in glomeruli of patients with idiopathic membranous nephropathy
Autore:
Horikoshi, S; Ebihara, I; Nakamura, T; Koide, H;
Indirizzi:
Koto Hosp, Dept Med, Koto Ku, Tokyo 136, Japan Koto Hosp Tokyo Japan 136Koto Hosp, Dept Med, Koto Ku, Tokyo 136, Japan Juntendo Univ, Sch Med, Dept Med, Tokyo 113, Japan Juntendo Univ Tokyo Japan 113 Univ, Sch Med, Dept Med, Tokyo 113, Japan Misato Junshin Hosp, Nephrol Unit, Misato, Saitama, Japan Misato Junshin Hosp Misato Saitama Japan ol Unit, Misato, Saitama, Japan
Titolo Testata:
NEPHRON
fascicolo: 3, volume: 81, anno: 1999,
pagine: 284 - 288
SICI:
0028-2766(199903)81:3<284:ADOMLI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASEMENT-MEMBRANE; MONOCLONAL-ANTIBODIES; IV COLLAGEN; GP-2 SUBUNIT; GLOMERULONEPHRITIS; GLYCOPROTEIN; ANTIGENS; TISSUES; RAT;
Keywords:
laminin A chain; monoclonal antibody; membranous nephropathy; glomerular basement membrane; subepithelial protrusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Koide, H Koto Hosp, Dept Med, Koto Ku, 6-8-5 Ojima, Tokyo 136, Japan Koto Hosp 6-8-5 Ojima Tokyo Japan 136 -5 Ojima, Tokyo 136, Japan
Citazione:
S. Horikoshi et al., "Abnormal distribution of mesangium-specific laminin in glomeruli of patients with idiopathic membranous nephropathy", NEPHRON, 81(3), 1999, pp. 284-288

Abstract

Using a monoclonal antibody, the distribution of the mesangium-specific laminin that binds only to the mesangium in normal kidney, was studied immunohistochemically in renal tissues obtained from patients with different glomerulonephritides including idiopathic membranous nephropathy. In minimal change nephrotic syndrome and IgA nephropathy, the mesangium-specific lamininstaining was restricted to the mesangium, as is observed in the normal kidney. However, in patients with idiopathic membranous nephropathy, the monoclonal antibody against the mesangium-specific laminin reacted with the glomerular peripheral capillary walls including subepithelial protrusions or 'spikes', as well as with the mesangium. These results suggest that the quality of laminin produced in response to the challenge of immune deposits in the peripheral capillary walls may be different from that in the rest of theglomerular basement membrane in idiopathic membranous nephropathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 09:57:57