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Titolo:
Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity
Autore:
Wu, ZD; Rosen, ED; Brun, R; Hauser, S; Adelmant, G; Troy, AE; McKeon, C; Darlington, GJ; Spiegelman, BM;
Indirizzi:
Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA HarvardUniv Boston MA USA 02115 a Farber Canc Inst, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ed, Dept Cell Biol, Boston, MA 02115 USA NIDKDD, Diabet Branch, NIH, Bethesda, MD 20892 USA NIDKDD Bethesda MD USA20892 , Diabet Branch, NIH, Bethesda, MD 20892 USA Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 , Dept Pathol, Houston, TX 77030 USA Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA Baylor CollMed Houston TX USA 77030 & Human Genet, Houston, TX 77030 USA
Titolo Testata:
MOLECULAR CELL
fascicolo: 2, volume: 3, anno: 1999,
pagine: 151 - 158
SICI:
1097-2765(199902)3:2<151:COCAAP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENHANCER-BINDING-PROTEIN; ACTIVATED RECEPTOR-GAMMA; NECROSIS-FACTOR-ALPHA; GENE-EXPRESSION; ADIPOCYTE DIFFERENTIATION; 3T3-L1 PREADIPOCYTES; ECTOPIC EXPRESSION; CELLS; PROMOTES; FAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Spiegelman, BM Harvard5Univ, Sch Med, Dana Farber Canc Inst, 44 Binney St,Boston, MA 0211 Harvard Univ 44 Binney St Boston MA USA 02115 ston, MA 0211
Citazione:
Z.D. Wu et al., "Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity", MOL CELL, 3(2), 1999, pp. 151-158

Abstract

Mice deficient in C/EBP alpha have defective development of adipose tissue, but the precise role of C/EBP alpha has not been defined. Fibroblasts from C/EBP alpha(-/-) mice undergo adipose differentiation through expression and activation of PPAR gamma, though several clear defects are apparent. C/EBP alpha-deficient adipocytes accumulate less lipid, and they do not induce endogenous PPAR gamma, indicating that cross-regulation between C/EBP alpha and PPAR gamma is important in maintaining the differentiated state. Thecells also show a complete absence of insulin-stimulated glucose transport, secondary to reduced gene expression and tyrosine phosphorylation for theinsulin receptor and IRS-1, These results define multiple roles for C/EBP alpha in adipogenesis and show that cross-regulation between PPAR gamma andC/EBP alpha is a key component of the transcriptional control of this celllineage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 04:48:07