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Titolo:
Creatine kinase, cell membrane and Duchenne muscular dystrophy
Autore:
Ozawa, E; Hagiwara, Y; Yoshida, M;
Indirizzi:
NCNP, Natl Inst Neurosci, Tokyo 187, Japan NCNP Tokyo Japan 187NCNP, Natl Inst Neurosci, Tokyo 187, Japan
Titolo Testata:
MOLECULAR AND CELLULAR BIOCHEMISTRY
fascicolo: 1-2, volume: 190, anno: 1999,
pagine: 143 - 151
SICI:
0300-8177(199901)190:1-2<143:CKCMAD>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE SARCOLEMMA; TORPEDO ELECTRIC ORGAN; GLYCOPROTEIN-COMPLEX; SARCOGLYCAN COMPLEX; TISSUE DISTRIBUTION; MDX MICE; CYTOSKELETAL PROTEIN; EXTRACELLULAR-MATRIX; BETA-SARCOGLYCAN; MOLECULAR-BASIS;
Keywords:
dystrophin; dystroglycans; sarcoglycans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
97
Recensione:
Indirizzi per estratti:
Indirizzo: Ozawa, E NCNP, Natl Inst Neurosci, 4-1-1 Ogawahigashi Cho Kodaira, Tokyo 187, Japan NCNP 4-1-1 Ogawahigashi Cho Kodaira Tokyo Japan 187 o 187, Japan
Citazione:
E. Ozawa et al., "Creatine kinase, cell membrane and Duchenne muscular dystrophy", MOL C BIOCH, 190(1-2), 1999, pp. 143-151

Abstract

In 1958 Professor Setsuro Ebashi found that serum creatine kinase activityis increased in patients suffering from various muscular dystrophies, especially Duchenne muscular dystrophy (DMD). He and others proposed that creatine kinase passes through the cell membrane as it is released from DMD muscle fibers. Since then, it has been found that dystrophin and dystrophin-associated proteins are connected to several other components including the basal laminaand subsarcolemmal cytoskeletal networks on the cell membrane, while dystrophin anchors these dystrophin-associated proteins to the actin filaments inside the muscle cell. In DMD muscle, dystrophin has been found to be absent and dystroglycans and sarcoglycans decreased. However, how creatine kinase molecules can pass through the DMD muscle cell membrane still remains unanswered. On the basis of recent findings on the structure of the protein layers which sandwich the lipid bilayer of muscle cell membranes, this essay stressesthe importance of these lipid bilayers in protecting creatine kinase release from protoplasma in normal muscle. It further indicates the possibility that the absence of dystrophin in DMD muscle during muscle contraction may result in temporal damage to the lipid bilayer. (Mol Cell Biochem 190: 143-151, 1999).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 17:30:58