Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Systemic lupus erythematosus, a disease associated with low levels of clusterin/ApoJ, an antiinflammatory protein
Autore:
Newkirk, MM; Apostolakos, P; Neville, C; Fortin, PR;
Indirizzi:
McGill Univ, Dept Med, Montreal Gen Hosp, Inst Res,Div Rheumatol, Montreal, McGill Univ Montreal PQ Canada H3G 1A4 Inst Res,Div Rheumatol, Montreal, McGillreal,, Dept Med, Montreal Gen Hosp, Inst Res,Div Clin Epidemiol, Mont McGill Univ Montreal PQ Canada H3G 1A4 Inst Res,Div Clin Epidemiol, Mont
Titolo Testata:
JOURNAL OF RHEUMATOLOGY
fascicolo: 3, volume: 26, anno: 1999,
pagine: 597 - 603
SICI:
0315-162X(199903)26:3<597:SLEADA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TERMINAL COMPLEMENT COMPLEX; APOLIPOPROTEIN-J/CLUSTERIN; GENE-EXPRESSION; VITRONECTIN; GROWTH; CELLS; LOCALIZATION; QUANTITATION; DEPOSITS; REGION;
Keywords:
alopecia; arthritis; clusterin; systemic lupus erythematosus; proteinuria;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Newkirk, MM McGillrUniv, Dept Med, Montreal Gen Hosp, Inst Res,Div Rheumatol, 1650 Ceda McGill Univ 1650 Cedar Ave Montreal PQ Canada H3G 1A4 650 Ceda
Citazione:
M.M. Newkirk et al., "Systemic lupus erythematosus, a disease associated with low levels of clusterin/ApoJ, an antiinflammatory protein", J RHEUMATOL, 26(3), 1999, pp. 597-603

Abstract

Objective. To measure the serum levels of clusterin, an antiinflammatory protein, which binds and inactivates complement, in patients with systemic lupus erythematosus (SLE) to determine whether the levels correlate with disease. Methods. The levels of serum clusterin were measured by ELISA in 80 patients with SLE (76 female, 4 male). Clinical and serological information was gathered on 115 visits. Overall disease activity scores were determined using the Systemic Lupus Activity Measure-Revised. Results, Serum clusterin levels were significantly decreased in patients with SLE and correlated inversely with disease activity (p < 0.00001). Low clusterin levels were significantly associated with skin ulcers (p < 0.0001), loss of hair (p = 0.002), proteinuria (p = 0.018), low platelet count (p = 0.03), and arthritis (p < 0.0001), The clusterin levels did not correlatewith either systemic complement consumption, as measured by C3 or C4, or with prednisone use. Conclusion. A highly significant correlation was observed between low levels of serum clusterin and a number of SLE disease features. This deficiencyof clusterin could directly or indirectly affect the disease process. Individuals lacking sufficient amounts of clusterin systemically likely have poor control of antibody mediated inflammation at sites of apoptosis where autoantigens are exposed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:26:05