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Titolo:
Regulation of guinea pig hepatic acyl-CoA : cholesterol acyltransferase activity by dietary fat saturation and cholesterol
Autore:
Sun, DM; Fernandez, ML; Lin, ECK; McNamara, DJ;
Indirizzi:
Univ Arizona, Dept Nutr Sci, Tucson, AZ 85721 USA Univ Arizona Tucson AZ USA 85721 ona, Dept Nutr Sci, Tucson, AZ 85721 USA Univ Arizona, Interdisciplinary Nutr Sci Program, Tucson, AZ 85721 USA Univ Arizona Tucson AZ USA 85721 y Nutr Sci Program, Tucson, AZ 85721 USA
Titolo Testata:
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
fascicolo: 3, volume: 10, anno: 1999,
pagine: 172 - 180
SICI:
0955-2863(199903)10:3<172:ROGPHA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-LIVER MICROSOMES; ESTERIFIED CHOLESTEROL; LIPID EXTRACTS; SUBSTRATE POOL; ACYLCOENZYME-A; COENZYME-A; METABOLISM; REDUCTASE; MEMBRANE; HAMSTER;
Keywords:
acyl-coA : cholesterol acyltransferase; liver; low density lipoprotein; dietary cholesterol; dietary fat; guinea pig;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Fernandez, ML Univ06269ecticut, Dept Nutr Sci, 3624 Horsebarn Rd Extens,U-17, Storrs, CT Univ Connecticut 3624 Horsebarn Rd Extens,U-17 Storrs CT USA06269
Citazione:
D.M. Sun et al., "Regulation of guinea pig hepatic acyl-CoA : cholesterol acyltransferase activity by dietary fat saturation and cholesterol", J NUTR BIOC, 10(3), 1999, pp. 172-180

Abstract

We measured the interactive effects of dietary cholesterol and Sat on the regulation of hepatic acyl-CoA: cholesterol acyltransferase (ACAT) activityand its relationship to hepatic microsomal lipid composition in guinea pigs fed 15 g/100 g (w/w) fat diets (corn oil, olive oil, or lard) with 0.01, 0.08, 0.17, or 0.33 g/100 g (w/w) added cholesterol. Guinea pigs exhibited a dose dependent increase in hepatic microsomal ACAT activity, with increasing levels of cholesterol intake (P < 0.001) in all dietary fat groups. Animals fed monounsaturated olive oil had the highest hepatic ACAT activity with the exception of the 0.33 g/100 g cholesterol diet (P < 0.001). There were no differences in ACAT activity with intake of polyunsaturated corn oil or saturated lard. Dietary cholesterol resulted in increased microsomal free cholesterol (FC) concentrations in a dose dependent manner but had no effects on microsomal phosphatidylcholine (PC) concentrations. Guinea pigs fedolive oil generally had the highest microsomal FC/PC molar ratios, and hepatic ACAT activities correlated significantly with this parameter After modification of the lipid compositions of the microsomes from guinea pigs fed the 12 test diets with FC/PC liposome treatment, microsomal ACAT activitiesremained significantly related to the microsomal FC/PC molar ratios, and dietary far type did not affect this correlation. Our findings do not support the hypothesis that the stimulation of hepatic ACAT activity with cholesterol intake is enhanced by polyunsaturated far intake. The data demonstratethat although dietary fat type and cholesterol amount have differential effects on hepatic ACAT activity, substrate availability, expressed as microsomal FC/PC molar ratio, is a major regulator of hepatic microsomal ACAT activity. (C) Elsevier Science Inc. 1999. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:47:59