Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MIRD pamphlet no. 15: Radionuclide S values in a revised dosimetric model of the adult head and brain
Autore:
Bouchet, LG; Bolch, WE; Weber, DA; Atkins, HL; Poston, JW;
Indirizzi:
Univ Florida, Dept Nucl & Radiol Engn, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 iol Engn, Gainesville, FL 32611 USA Univ Calif Davis, Dept Radiol, Sacramento, CA 95817 USA Univ Calif Davis Sacramento CA USA 95817 Radiol, Sacramento, CA 95817 USA SUNY Stony Brook, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 rook, Stony Brook, NY 11794 USA Texas A&M Univ, Dept Nucl Engn, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 l Engn, College Stn, TX 77843 USA
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 3, volume: 40, anno: 1999,
pagine: 62S - 101S
SICI:
0161-5505(199903)40:3<62S:MPN1RS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; DOPAMINE-RECEPTOR; L-3-IODO-ALPHA-METHYL TYROSINE; IMAGING AGENT; SPECT; TUMORS; BIODISTRIBUTION; RADIOLIGAND; PET; OXYGEN-15-WATER;
Keywords:
brain dosimetry; neuroimaging; suborgan dosimetry; MIRD schema;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Bolch, WE Univ Florida, Dept Nucl & Radiol Engn, Gainesville, FL 32611 USAUniv Florida Gainesville FL USA 32611 Gainesville, FL 32611 USA
Citazione:
L.G. Bouchet et al., "MIRD pamphlet no. 15: Radionuclide S values in a revised dosimetric model of the adult head and brain", J NUCL MED, 40(3), 1999, pp. 62S-101S

Abstract

Current dosimetric models of the brain and head lack the anatomic detail needed to provide the physical data necessary for suborgan brain dosimetry. During the last decade, several new radiopharmaceuticals have been introduced for brain imaging. The marked differences of these tracers in tissue specificity within the train and their increasing use for diagnostic studies support the need for a more anthropomorphic model of the human brain and head for use in estimating regional absorbed dose within the brain and its adjacent structures. Methods: A new brain model has been developed that includes eight subregions: the caudate nuclei, the cerebellum, the cerebral cortex, the lateral ventricles, the lentiform nuclei, the thalami, the third ventricle and the white matter. This brain model is incorporated within a total revision of the head model presented in MIRD Pamphlet No. 5 Revised. Modifications include the addition of the eyes, the teeth, the mandible, an upper facial region, a neck region and the cerebrospinal fluid within both thecranial and spinal regions. Results: absorbed fractions of energy for photon and electron sources located in 14 source regions within the new model were calculated using the EGS4 Monte Carlo radiation transport code for particles in the energy range 10 keV-4 MeV. These absorbed fractions were then used along with radionuclide decay data to generate S values for 24 radionuclides that are used in clinical or investigational studies of the brain, 12 radionuclides that localize within the cranium and spinal skeleton and 12radionuclides that selectively localize in the thyroid gland. Conclusion: A substantial revision to the dosimetric model of the adult head and brain originally published in MIRD Pamphlet No. 5 Revised is presented. This revision supports suborgan brain dosimetry for a variety of radiopharmaceuticals used in neuroimaging. Dose calculations for the neuroimaging agent I-123-tropane provide an example of the new model and yield mean brain doses thatare consistent with published values. However, the absorbed dose to subregions within the brain such as the caudate and lentiform nuclei may exceed the average brain dose by a factor of up to 5.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 06:10:39