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Titolo:
Dissociation in effects of lesions of the nucleus accumbens core and shellon appetitive Pavlovian approach behavior and the potentiation of conditioned reinforcement and locomotor activity by D-Amphetamine
Autore:
Parkinson, JA; Olmstead, MC; Burns, LH; Robbins, TW; Everitt, BJ;
Indirizzi:
Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England Univ Cambridge Cambridge England CB2 3EB hol, Cambridge CB2 3EB, England Queens Univ, Dept Psychol, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 chol, Kingston, ON K7L 3N6, Canada Neurex, Menlo Park, CA 94025 USA Neurex Menlo Park CA USA 94025Neurex, Menlo Park, CA 94025 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 6, volume: 19, anno: 1999,
pagine: 2401 - 2411
SICI:
0270-6474(19990315)19:6<2401:DIEOLO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULUS REWARD ASSOCIATIONS; VENTRAL STRIATUM; EXTRACELLULAR DOPAMINE; EXCITOTOXIC LESIONS; PREFRONTAL CORTEX; 6-HYDROXYDOPAMINE LESIONS; BASOLATERAL AMYGDALA; EFFERENT PROJECTIONS; GLUCOSE-UTILIZATION; PLACE PREFERENCE;
Keywords:
ventral striatum; reward; dopamine; psychomotor stimulant; associative learning; drugs of abuse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Everitt, BJ Univ Cambridge, Dept Expt Psychol, Downing St, Cambridge CB2 3EB, England Univ Cambridge Downing St Cambridge England CB2 3EB , England
Citazione:
J.A. Parkinson et al., "Dissociation in effects of lesions of the nucleus accumbens core and shellon appetitive Pavlovian approach behavior and the potentiation of conditioned reinforcement and locomotor activity by D-Amphetamine", J NEUROSC, 19(6), 1999, pp. 2401-2411

Abstract

Dopamine release within the nucleus accumbens (NAcc) has been associated with both the rewarding and locomotor-stimulant effects of abused drugs. Thefunctions of the NAcc core and shell were investigated in mediating amphetamine-potentiated conditioned reinforcement and locomotion. Rats were initially trained to associate a neutral stimulus (Pavlovian CS) with food reinforcement (US). After excitotoxic lesions that selectively destroyed either the NAcc core or shell, animals underwent additional CS-US training sessions and then were tested for the acquisition of a new instrumental response that produced the CS acting as a conditioned reinforcer (CR). Animals were infused intra-NAcc with D-amphetamine (0, 1, 3, 10, or 20 mu g) before each session. Shell lesions affected neither Pavlovian nor instrumental conditioning but completely abolished the potentiative effect of intra-NAcc amphetamine on responding with CR. Core-lesioned animals were impaired during the Pavlovian retraining sessions but showed no deficit in the acquisition of responding with CR. However, the selectivity in stimulant-induced potentiation of the CR lever was reduced, as intra-NAcc amphetamine infusions dose-dependently increased responding on both the CR lever and a nonreinforced (control) lever. Shell lesions produced hypoactivity and attenuated amphetamine-induced activity. In contrast, core lesions resulted in hyperactivity andenhanced the locomotor-stimulating effect of amphetamine. These results indicate a functional dissociation of subregions of the NAcc; the shell is a critical site for stimulant effects underlying the enhancement of responding with CR and locomotion after intra-NAcc injections of amphetamine, whereas the core is implicated in mechanisms underlying the expression of CS-US associations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 04:52:32