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Titolo:
The superior olivary nucleus and its influence on nucleus laminaris: A source of inhibitory feedback for coincidence detection in the avian auditory brainstem
Autore:
Yang, LC; Monsivais, P; Rubel, EW;
Indirizzi:
Univ5Washington, Virginia Merrill Bloedel Hearing Res Ctr, Seattle, WA 9819 Univ Washington Seattle WA USA 98195 el Hearing Res Ctr, Seattle, WA 9819 Univ Washington, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 d & Neck Surg, Seattle, WA 98195 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 6, volume: 19, anno: 1999,
pagine: 2313 - 2325
SICI:
0270-6474(19990315)19:6<2313:TSONAI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERAURAL TIME DIFFERENCES; COCHLEAR NUCLEUS; BARN OWL; N-LAMINARIS; SYNAPTIC TRANSMISSION; GABAERGIC NEURONS; AMPA RECEPTORS; IN-VITRO; STEM; CHICKEN;
Keywords:
avian superior olivary nucleus; GABAergic inhibition; coincidence detection; nucleus laminaris; membrane conductance; shunting effect;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Rubel, EW Univtle,hington, Virginia Merrill Bloedel Hearing Res Ctr, Box 357923, Seat Univ Washington Box 357923 Seattle WA USA 98195 Box 357923, Seat
Citazione:
L.C. Yang et al., "The superior olivary nucleus and its influence on nucleus laminaris: A source of inhibitory feedback for coincidence detection in the avian auditory brainstem", J NEUROSC, 19(6), 1999, pp. 2313-2325

Abstract

Located in the ventrolateral region of the avian brainstem, the superior olivary nucleus (SON) receives inputs from nucleus angularis (NA) and nucleus laminaris (NL) and projects back to NA, NL, and nucleus magnocellularis (NM). The reciprocal connections between the SON and NL are of particular interest because they constitute a feedback circuit for coincidence detection. In the present study, the chick SON was investigated. In vivo tracing studies show that the SON projects predominantly to the ipsilateral NM, NL, and NA. In vitro whole-cell recording reveals single-cell morphology, firing properties, and postsynaptic responses. SON neurons are morphologically andphysiologically suited for temporal integration; their firing patterns do not reflect the temporal structure of their excitatory inputs. Of most interest, direct stimulation of the SON evokes long-lasting inhibition in NL neurons. The inhibition blocks both intrinsic spike generation and orthodromically evoked activity in NL neurons and can be eliminated by bicuculline methiodide, a potent antagonist for GABA, receptor-mediated neurotransmission. These results strongly suggest that the SON provides GABAergic inhibitoryfeedback to laminaris neurons. We discuss a mechanism whereby SON-evoked GABAergic inhibition can influence the coding of interaural time differencesfor sound localization in the avian auditory brainstem.

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Documento generato il 10/07/20 alle ore 15:49:34