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Titolo:
Specification of distinct dopaminergic neural pathways: Roles of the Eph family receptor EphB1 and ligand ephrin-B2
Autore:
Yue, Y; Widmer, DAJ; Halladay, AK; Cerretti, DP; Wagner, GC; Dreyer, JL; Zhou, RP;
Indirizzi:
RutgersJState Univ, Coll Pharm, Canc Res Lab, Dept Biol Chem, Piscataway, N Rutgers State Univ Piscataway NJ USA 08855 Dept Biol Chem, Piscataway, N Rutgers State Univ, Dept Psychol, Piscataway, NJ 08855 USA Rutgers State Univ Piscataway NJ USA 08855 chol, Piscataway, NJ 08855 USA Immunex Res & Dev Corp, Seattle, WA 98101 USA Immunex Res & Dev Corp Seattle WA USA 98101 v Corp, Seattle, WA 98101 USA Univ Fribourg, Dept Biochem, CH-1700 Fribourg, Switzerland Univ Fribourg Fribourg Switzerland CH-1700 CH-1700 Fribourg, Switzerland
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 6, volume: 19, anno: 1999,
pagine: 2090 - 2101
SICI:
0270-6474(19990315)19:6<2090:SODDNP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINAL GANGLION-CELLS; TYROSINE KINASES; NUCLEUS-ACCUMBENS; HORSERADISH-PEROXIDASE; EFFERENT CONNECTIONS; CONTAINING NEURONS; VENTRAL TEGMENTUM; IN-VITRO; RAT; COCAINE;
Keywords:
axonal guidance; dopaminergic pathways; Eph family receptors; ephrins; drug addiction; plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Zhou, RP RutgersJState Univ, Coll Pharm, Canc Res Lab, Dept Biol Chem, Piscataway, N Rutgers State Univ Piscataway NJ USA 08855 l Chem, Piscataway, N
Citazione:
Y. Yue et al., "Specification of distinct dopaminergic neural pathways: Roles of the Eph family receptor EphB1 and ligand ephrin-B2", J NEUROSC, 19(6), 1999, pp. 2090-2101

Abstract

Dopaminergic neurons in the substantia nigra and ventral tegmental area project to the caudate putamen and nucleus accumbens/olfactory tubercle, respectively, constituting mesostriatal and mesolimbic pathways. The molecular signals that confer target specificity of different dopaminergic neurons are not known. We now report that EphB1 and ephrin-B2, a receptor and ligand of the Eph family, are candidate guidance molecules for the development of these distinct pathways. EphB1 and ephrin-B2 are expressed in complementarypatterns in the midbrain dopaminergic neurons and their targets, and the ligand specifically inhibits the growth of neurites and induces the cell loss of substantia nigra, but not ventral tegmental, dopaminergic neurons. These studies suggest that the ligand-receptor pair may contribute to the establishment of distinct neural pathways by selectively inhibiting the neuriteoutgrowth and cell survival of mistargeted neurons. In addition, we show that ephrin-B2 expression is upregulated by cocaine and amphetamine in adultmice, suggesting that ephrin-B2/EphB1 interaction may play a role in drug-induced plasticity in adults as well.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:04:08