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Titolo:
GABA- and glutamate-activated channels in green fluorescent protein-taggedgonadotropin-releasing hormone neurons in transgenic mice
Autore:
Spergel, DJ; Kruth, U; Hanley, DF; Sprengel, R; Seeburg, PH;
Indirizzi:
Max Planck Inst Med Res, Dept Mol Neurosci, D-69120 Heidelberg, Germany Max Planck Inst Med Res Heidelberg Germany D-69120 0 Heidelberg, Germany
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 6, volume: 19, anno: 1999,
pagine: 2037 - 2050
SICI:
0270-6474(19990315)19:6<2037:GAGCIG>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GNRH NEURONS; NMDA RECEPTORS; GENE-EXPRESSION; FEMALE RATS; MOUSE; SUBUNIT; BRAIN; IDENTIFICATION; SECRETION; SLICES;
Keywords:
diagonal band of Broca; GABA; GFP; glutamate; GnRH; hypothalamus; median eminence; organum vasculosum of the lamina terminalis; preoptic area; transgenic mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Spergel, DJ Max Planck Inst Med Res, Dept Mol Neurosci, Jahnstr 29, D-69120 Heidelberg, Max Planck Inst Med Res Jahnstr 29 Heidelberg Germany D-69120
Citazione:
D.J. Spergel et al., "GABA- and glutamate-activated channels in green fluorescent protein-taggedgonadotropin-releasing hormone neurons in transgenic mice", J NEUROSC, 19(6), 1999, pp. 2037-2050

Abstract

Mice were generated expressing green fluorescent protein (GFP) under the control of the gonadotropin-releasing hormone (GnRH) promoter. Green fluorescence was observed in, and restricted to, GnRH-immunopositive neuronal somata in the olfactory bulb, ganglion terminale, septal nuclei, diagonal band of Broca (DBB), preoptic area (POA), and caudal hypothalamus, as well as GnRH neuronal dendrites and axons, including axon terminals in the median eminence and organum vasculosum of the lamina terminalis (OVLT). Whole-cell recordings from GFP-expressing GnRH neurons in the OVLT-POA-DBB region revealed a firing pattern among GFP-expressing GnRH neurons distinct from that ofnonfluorescent neurons. Nucleated patches of GFP-expressing GnRH neurons exhibited pronounced responses to fast application of GABA and smaller responses to L-glutamate and AMPA. One-fifth of the nucleated patches responded to NMDA. The GABA-A, AMPA, and NMDA receptor channels on GnRH neurons mediating these responses may play a role in the modulation of GnRH secretory oscillations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 03:24:55