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Titolo:
High Epstein-Barr virus serum load and elevated titers of anti-ZEBRA antibodies in patients with EBV-harboring tumor cells of Hodgkin's disease
Autore:
Drouet, E; Brousset, P; Fares, F; Icart, J; Verniol, C; Meggetto, F; Schlaifer, D; Desmorat-Coat, H; Rigal-Huguet, F; Niveleau, A; Delsol, G;
Indirizzi:
Univ Grenoble 1, Lab Virol & Immunol, F-38706 La Tronche, France Univ Grenoble 1 La Tronche France F-38706 ol, F-38706 La Tronche, France Ctr Hosp Univ, Lab Cent Anat Pathol, Toulouse, France Ctr Hosp Univ Toulouse France v, Lab Cent Anat Pathol, Toulouse, France Univ Lyon 1, Ctr Commun Quantimetrie, Lyon, France Univ Lyon 1 Lyon France v Lyon 1, Ctr Commun Quantimetrie, Lyon, France Ctr Hosp Univ, Serv Virol, Toulouse, France Ctr Hosp Univ Toulouse France r Hosp Univ, Serv Virol, Toulouse, France Ctr Hosp Univ, Serv Hematol Clin, Toulouse, France Ctr Hosp Univ Toulouse France Univ, Serv Hematol Clin, Toulouse, France
Titolo Testata:
JOURNAL OF MEDICAL VIROLOGY
fascicolo: 4, volume: 57, anno: 1999,
pagine: 383 - 389
SICI:
0146-6615(199904)57:4<383:HEVSLA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPLICATION-ACTIVATOR PROTEIN; POLYMERASE CHAIN-REACTION; REED-STERNBERG CELLS; NASOPHARYNGEAL CARCINOMA; INFECTIOUS-MONONUCLEOSIS; GENE-EXPRESSION; PRODUCTS; LYMPHOMA; LYMPHOCYTES; BIOPSIES;
Keywords:
EBV replication; PCR; ZEBRA (BZLF1); Hodgkin's lymphoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Drouet, E Univancenoble 1, Lab Virol & Immunol, Domaine Merci, F-38706 La Tronche, Fr Univ Grenoble 1 Domaine Merci La Tronche France F-38706 che, Fr
Citazione:
E. Drouet et al., "High Epstein-Barr virus serum load and elevated titers of anti-ZEBRA antibodies in patients with EBV-harboring tumor cells of Hodgkin's disease", J MED VIROL, 57(4), 1999, pp. 383-389

Abstract

Hodgkin's disease is commonly associated with EBV latent infection. The incidence of EBV reactivation (active infection or EBV infection with replicative cycle) was evaluated in a series of 30 patients with untreated Hodgkin's disease (except for one case with chronic lymphocytic leukemia) by quantitation of EBV DNA and titration of anti-ZEBRA antibodies in serum samples. DNA was detected in serum (>2.5 x 10(2) genomes/ml) in 15 of 30 patients and was more frequent in Hodgkin's disease with EBV-positive Reed-Sternberg cells (10/12) than in EBV-negative cases (5/18), (P< 0.01). Of interest wasthe demonstration that viremia correlated well with increased titers of anti-ZEBRA IgG and/or standard serological profiles of EBV reactivation (12/15), (P < 0.05). However the lack of EBV replicative cycle in Reed-Sternbergcells (negative for ZEBRA antigen and early antigen BHLF1) suggests that the viral replication occurs in a nonneoplastic cell compartment rather thanin tumor cells. The measurement of EBV DNA loads and the titration of anti-ZEBRA antibodies shed new lights on the link between activation of EBV replication and Hodgkin's disease: these serological markers together with thedetermination of the EBV status of the tumor suggest that replication of the viral genome occurs with a decreased efficiency of the immune system, thus allowing progression of the tumor. (C) 1999 Wiley-Liss, Inc.

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Documento generato il 26/10/20 alle ore 23:29:30