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Titolo:
Infection of apheresis cells by parvovirus B19
Autore:
Hemauer, A; Gigler, A; Gareus, R; Reichle, A; Wolf, H; Modrow, S;
Indirizzi:
Inst Med Mikrobiol & Hyg, D-93053 Regensburg, Germany Inst Med Mikrobiol &Hyg Regensburg Germany D-93053 Regensburg, Germany Univ,Klinikum Regensburg, Abt Hamatol & Internist Onkol, D-93053 Regensburg Univ Klinikum Regensburg Regensburg Germany D-93053 , D-93053 Regensburg
Titolo Testata:
JOURNAL OF GENERAL VIROLOGY
, volume: 80, anno: 1999,
parte:, 3
pagine: 627 - 630
SICI:
0022-1317(199903)80:<627:IOACBP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINE MB-02; REPLICATION; DIFFERENTIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Modrow, S Instmany Mikrobiol & Hyg, Franz Josef Str Allee 11, D-93053 Regensburg, Ger Inst Med Mikrobiol & Hyg Franz Josef Str Allee 11 Regensburg Germany D-93053
Citazione:
A. Hemauer et al., "Infection of apheresis cells by parvovirus B19", J GEN VIROL, 80, 1999, pp. 627-630

Abstract

Parvovirus B19 is the only member of the Parvoviridae family known to cause disease in humans. Owing to the high level of cell tropism the virus can only replicate in proliferating and differentiating erythroid precursor cells, which are present in human bone marrow and foetal liver. As human bone marrow is very difficult to obtain, an alternative in vitro system for the propagation of B19 virus has been developed, based on the application of mobilized haemapoietic progenitor (apheresis) cells. These cells are routinely harvested from cancer patients after treatment with recombinant human granulocyte/macrophage colony-stimulating factor. Replication of parvovirus B19 in vitro is possible in these cells after stimulation with erythropoietin. Therefore, this system is an easily, accessible alternative to the use ofhuman bone marrow in parvovirus B19 infection assays.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:19:22