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Titolo:
NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily
Autore:
Cantoni, C; Bottino, C; Vitale, M; Pessino, A; Augugliaro, R; Malaspina, A; Parolini, S; Moretta, L; Moretta, A; Biassoni, R;
Indirizzi:
Ctr Biotechnol Avanzate, Lab Immunopatol, I-16132 Genoa, Italy Ctr Biotechnol Avanzate Genoa Italy I-16132 opatol, I-16132 Genoa, Italy Ist Nazl Ric Canc, I-16132 Genoa, Italy Ist Nazl Ric Canc Genoa Italy I-16132 azl Ric Canc, I-16132 Genoa, Italy Univ Genoa, Dipartimento Med Sperimentale, I-16132 Genoa, Italy Univ Genoa Genoa Italy I-16132 to Med Sperimentale, I-16132 Genoa, Italy Univ Brescia, Dipartimento Sci Biomed & Biotecnol, I-25100 Brescia, Italy Univ Brescia Brescia Italy I-25100 d & Biotecnol, I-25100 Brescia, Italy
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 5, volume: 189, anno: 1999,
pagine: 787 - 795
SICI:
0022-1007(19990301)189:5<787:NATRII>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHIBITORY PATHWAYS; MOLECULAR-CLONING; LYMPHOCYTES; GENE; INTERLEUKIN-2; PHOSPHATASE; PROTEINS; SIGNALS; DOMAINS;
Keywords:
natural killer cells; activating receptor; natural cytotoxicity; immunoglobulin superfamily; cDNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Moretta, L Ctralyotechnol Avanzate, Lab Immunopatol, Lgo R Benzi 10, I-16132 Genoa, It Ctr Biotechnol Avanzate Lgo R Benzi 10 Genoa Italy I-16132 It
Citazione:
C. Cantoni et al., "NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily", J EXP MED, 189(5), 1999, pp. 787-795

Abstract

Surface receptors involved in natural killer (NK) cell triggering during the process of tumor cell lysis have recently been identified. Of these receptors, NKp44 is selectively expressed by IL-2-activated NK cells and may contribute to the increased efficiency of activated. NK cells to mediate tumor cell lysis, Here we describe the molecular cloning of NKp44. Analysis of the cloned cDNA indicated that NKp44 is a novel transmembrane glycoprotein belonging to the Immunoglobulin superfamily characterized by a single extracellular V-type domain. The charged amino acid lysine in the transmembrane region may be involved in the association of NKp44 with the signal transducing molecule killer activating receptor-associated polypeptide (KARAP)/DAP12. These molecules were found to be crucial for the surface expression of NKp44. In agreement with data of NKp44 surface expression, the NKp44 transcripts were strictly confined to activated NK cells and to a minor subset of TCR-gamma/delta(+) T lymphocytes. Unlike genes coding for other receptors involved in NK cell triggering or inhibition, the NKp44 gene is on human chromosome 6.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 20:36:46