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Titolo:
Dissolution of synthetic hydroxyapatite in the presence of acidic polypeptides
Autore:
Poumier, F; Schaad, P; Haikel, Y; Voegel, JC; Gramain, P;
Indirizzi:
INSERM, U424, F-67000 Strasbourg, France INSERM Strasbourg France F-67000 NSERM, U424, F-67000 Strasbourg, France Ecole Natl Super Chim, HMM, CNRS, F-34296 Montpellier 5, France Ecole NatlSuper Chim Montpellier France 5 F-34296 Montpellier 5, France
Titolo Testata:
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
fascicolo: 2, volume: 45, anno: 1999,
pagine: 92 - 99
SICI:
0021-9304(199905)45:2<92:DOSHIT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
IONIC ADSORPTION; KINETICS; EQUILIBRIUM; POWDER; ENAMEL;
Keywords:
apatite; demineralization; polypeptides; proteins; adsorption;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Voegel, JC INSERM, U424, 11 Rue Humann, F-67000 Strasbourg, France INSERM 11 Rue Humann Strasbourg France F-67000 asbourg, France
Citazione:
F. Poumier et al., "Dissolution of synthetic hydroxyapatite in the presence of acidic polypeptides", J BIOMED MR, 45(2), 1999, pp. 92-99

Abstract

This article deals with the effect of two acidic polypeptides [polyaspartic acid (PA) and polyglutamic acid (PG)] onto hydroxyapatite (HAP) dissolution by separately considering their influence when they are present only at the HAP interface and when they are both adsorbed and present in the bulk solution. We first: determined the amount of adsorbed PA and PG at pH 7.0 and 5.0 onto 10 mg of HAP. Dissolution experiments were performed at pH 5.0 under pH stat conditions by continuously following the consumed protons and released calcium versus time with the aid of specific electrodes. The released phosphate ions were determined by spectrophotometric analysis. The datashow that, because of their calcium chelating properties, the polypeptidesact as a driving force for HAP dissolution when PA and PC remain present in solution and the interfacial beneficial effect of the adsorbed peptides is erased by the chelating properties of PA and PG present in the solution. When the polypeptides are only adsorbed at the interface, even if a partialPA or PG desorption occurs, HAP dissolution inhibition is still observed. (C) 1999 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:42:38