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Titolo: Interleukin-8 potentiates the effect of interleukin-1-induced uterine contractions
Autore: Khatun, S; Kanayama, N; Belayet, HM; Yonezawa, M; Kobayashi, T; Terao, T;
- Indirizzi:
- Hamamatsu2,niv, Sch Med, Dept Obstet & Gynaecol, Hamamatsu, Shizuoka 431319 Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 amamatsu, Shizuoka 431319
- Titolo Testata:
- HUMAN REPRODUCTION
fascicolo: 2,
volume: 14,
anno: 1999,
pagine: 560 - 565
- SICI:
- 0268-1161(199902)14:2<560:IPTEOI>2.0.ZU;2-W
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- ACTIVATING PEPTIDE-1 INTERLEUKIN-8; NECROSIS-FACTOR-ALPHA; HUMAN DECIDUAL CELLS; POLYMORPHONUCLEAR LEUKOCYTES; PROSTAGLANDIN BIOSYNTHESIS; INFLAMMATORY MEDIATORS; AMNIOTIC-FLUID; PARTURITION; NEUTROPHIL; LABOR;
- Keywords:
- interleukin-1; interleukin-8; neutrophil influx; prostaglandin E-2; uterine contraction;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Clinical Medicine
- Life Sciences
- Citazioni:
- 36
- Recensione:
- Indirizzi per estratti:
- Indirizzo: Kanayama, N Hamamatsu Univ, Sch Med, Dept Obstet & Gynaecol, 3600 Handa Cho, Hamamatsu, Hamamatsu Univ 3600 Handa Cho Hamamatsu Shizuoka Japan 4313192
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- Citazione:
- S. Khatun et al., "Interleukin-8 potentiates the effect of interleukin-1-induced uterine contractions", HUM REPR, 14(2), 1999, pp. 560-565
Abstract
The aim of this research was to study the effect of exogenous interleukin (IL)-8, IL-1 and IL-8 + IL-1 on uterine contractions in rabbits. Four equalgroups of non-pregnant rabbits (n = 24) were investigated using either placebo or experimental drugs in the form of vaginal suppositories. The suppositories contained human recombinant IL-8 (200 ng), IL-1 (200 ng), IL-8 (200ng) + IL-1 (200 ng) or vehicle (Witepsol base, 500 mu l). Subsequently, the plasma concentration of prostaglandin (PG) E-2 was estimated 3 h after the last dose of treatment. Neutrophil infiltration in the endometrial tissuewas studied with anti-rabbit RT2 staining. Suppositories with IL-1 and IL-8 + IL-1 produced contractile responses with increased frequency (P < 0.003, P < 0.0005) and amplitude (P < 0.0001) in vivo, compared with vehicle. IL-1 and IL-8 + IL-1 also caused similar contractile effects with increased frequency (P < 0.01, P < 0.0007) and amplitude (P < 0.0001) in an in-vitro experiment than vehicle, The frequency and amplitude of uterine contractionswere more significant with IL-8 + IL-1 than that of IL-1, both in vivo (P < 0.002, P < 0.05) and in vitro (P < 0.005, P < 0.01), IL-8 did not induce any contractions. Prostaglandin concentration was increased similar to 8-fold with IL-8 + IL-1 (P < 0.0001) and 2.5-fold with IL-1 treatment (P < 0.0001). Neutrophil numbers were significantly increased,vith IL-8 + IL-1 > IL-8 > IL-1 (P < 0.002, P < 0.0003 and P < 0.008) compared with vehicle. Our data suggest that IL-8 stimulates IL-1-induced uterine contractions through PGE(2) production and could be an important process during labour and delivery.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:02:35