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Titolo:
Induction of macrophage migration inhibitory factor in human ovary by human chorionic gonadotrophin
Autore:
Wada, S; Kudo, T; Kudo, M; Sakuragi, N; Hareyama, H; Nishihira, J; Fujimoto, S;
Indirizzi:
Hokkaido608638,Sch Med, Dept Obstet & Gynecol, Kita Ku, Sapporo, Hokkaido 0 Hokkaido Univ Sapporo Hokkaido Japan 0608638 Kita Ku, Sapporo, Hokkaido 0 HokkaidoJapan, Sch Med, Cent Res Inst, Kita Ku, Sapporo, Hokkaido 0608638,Hokkaido Univ Sapporo Hokkaido Japan 0608638 , Sapporo, Hokkaido 0608638,
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 2, volume: 14, anno: 1999,
pagine: 395 - 399
SICI:
0268-1161(199902)14:2<395:IOMMIF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRANULOSA-CELLS; RAT OVARY; OVULATION; CYTOKINES; INTERLEUKIN-1-BETA; LOCALIZATION; PURIFICATION; FOLLICLES; SYNTHASE; EMBRYOS;
Keywords:
human chorionic gonadotrophin; in-vitro fertilization; macrophage; migration inhibitory factor; ovulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Wada, S Hokkaidokkaido Sch Med, Dept Obstet & Gynecol, Kita Ku, N15,W7, Sapporo, Ho Hokkaido Univ N15,W7 Sapporo Hokkaido Japan 0608638 7, Sapporo, Ho
Citazione:
S. Wada et al., "Induction of macrophage migration inhibitory factor in human ovary by human chorionic gonadotrophin", HUM REPR, 14(2), 1999, pp. 395-399

Abstract

The role of macrophage migration inhibitory factor (MIF) in human ovarian function remains obscure. The aim of this study was to investigate how MIF was related to ovulation by quantitative analysis of serum, follicular fluid and culture medium of granulosa cells obtained from in-vitro fertilization (IVF) and embryo transfer patients. Serum MIF concentrations in ovarian stimulation cycles for IVF-embryo transfer were higher at day 1 (median 92.6ng/ml), which took place 35 h after human chorionic gonadotrophin (HCG) administration and just before the retrieval of oocytes, than those before day -6 (12.1 ng/ml), at day -5 to about day 0 (17.5 ng/ml) or at day 2 to about day 14 (8.2 ng/ml). MIF concentrations in the follicular fluid (113.4 ng/ml) obtained in ovarian stimulation cycles for IVF-embryo transfer were significantly higher than in serum (72.0 ng/ml) collected at the same time. MIF concentrations in the follicular fluid in natural cycles were higher in the ovulatory phase (51.6 ng/ml) than in the late follicular phase (13.8 ng/ml). MIF concentrations in the culture media of granulosa cells increased from 3.2 ng/ml to 7.2 ng/ml with HCG stimulation, and decreased from 2.4 ng/ml to 1.2 ng/ml when stimulation was withheld. These results indicate thatHCG can induce the elevation of serum and follicular fluid MIF concentrations through the stimulation of ovarian cells, and that MIF is probably involved in the mechanism of ovulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 23:50:45